Usefulness of total cholesterol/HDL-cholesterol ratio in the management of diabetic dyslipidaemia

• Published in: Diabetic medicine 2005-01, Vol.22 (1), p.26-31
• Main Authors: Gimeno-Orna, J. A., Faure-Nogueras, E., Sancho-Serrano, M. A.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; cardiovascular disease; Cholesterol - blood; Cholesterol, HDL - blood; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - blood; diabetic dyslipidaemia; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiologic Methods; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Hyperlipidemias - blood; Male; Medical sciences; Middle Aged; TC/HDL ratio
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2004.01341.x

Aims  Our aim was to evaluate the usefulness of the total cholesterol/HDL‐cholesterol ratio (TC/HDL) in predicting the cardiovascular risk of Type 2 diabetic patients. Methods  Prospective cohort study with inclusion of 418 Type 2 diabetic individuals with follow‐up until the appearance of a cardiovascular event. The predictive power of updated mean lipid values during follow‐up was analysed by means of Cox proportional hazard models. An estimate was made of the relative risk (RR) conferred by high levels of TC/HDL stratified by LDL‐cholesterol levels. Results  Sixty‐six cardiovascular events occurred during an average follow‐up of 4.7 years (sd 1.5). The main lipid predictor of vascular events was mean TC/HDL ratio [hazard ratio (HR) = 1.46; 95% confidence interval (CI) 1.25, 1.7; P