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Integrating Demographic and Epidemiological Approaches to Research on HIV/AIDS: The Proximate-Determinants Framework

This article presents a conceptual framework for the study of the distribution and determinants of human immunodeficiency virus (HIV) infection in populations, by combining demographic and epidemiological approaches. The proximate-determinants framework has been applied extensively in the study of f...

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Published in:The Journal of infectious diseases 2005-02, Vol.191 (Supplement-1), p.S61-S67
Main Authors: Boerma, J. Ties, Weir, Sharon S.
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Language:English
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description This article presents a conceptual framework for the study of the distribution and determinants of human immunodeficiency virus (HIV) infection in populations, by combining demographic and epidemiological approaches. The proximate-determinants framework has been applied extensively in the study of fertility and child survival in developing countries. Key to the framework is the identification of a set of variables, called “proximate determinants,” that can be influenced by changes in contextual variables or by interventions and that have a direct effect on biological mechanisms to influence health outcomes. In HIV research, the biological mechanisms are the components that determine the reproductive rate of infection. The proximate-determinants framework can be used in study design, in the analysis and interpretation of risk factors or intervention studies that include both biological and behavioral data, and in ecological studies
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source Oxford Journals Online
subjects AIDS
Child, Preschool
Condoms
Demography
Epidemiology
Fertility
HIV
HIV infections
HIV Infections - epidemiology
HIV Infections - mortality
HIV Infections - transmission
Human immunodeficiency virus
Humans
Infant
Infant, Newborn
Infections
Models, Statistical
Mortality
Research Design
Risk Factors
Sexual transmission
Socioeconomic Factors
Theory and Methods
Transmission efficiency
title Integrating Demographic and Epidemiological Approaches to Research on HIV/AIDS: The Proximate-Determinants Framework
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