Accelerated aqueous aging simulation of in vivo oxidation for gamma-sterilized UHMWPE

In vivo oxidation of gamma air‐sterilized ultrahigh‐molecular‐weight polyethylene (UHMWPE) has been observed when joint replacement hip and knee components are explanted during revision surgery. The purpose of the present study was to extend a previously published accelerated aging protocol for gamm...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2009-07, Vol.90B (1), p.368-372
Main Authors: Kurtz, Steven M., Siskey, Ryan L., Dumbleton, John
Format: Article
Language:English
Subjects:
accelerated aging methods
Gamma Rays
hydroperoxides
oxidation
Oxidation-Reduction
Polyethylenes
Spectroscopy, Fourier Transform Infrared
UHMWPE
ultrahigh-molecular-weight polyethylene
Water
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In vivo oxidation of gamma air‐sterilized ultrahigh‐molecular‐weight polyethylene (UHMWPE) has been observed when joint replacement hip and knee components are explanted during revision surgery. The purpose of the present study was to extend a previously published accelerated aging protocol for gamma‐sterilized UHMWPE. Unsterilized and gamma‐sterilized GUR 1150 resin samples were aged in phosphate‐buffered saline (PBS) at 40 or 50°C for up to 52 weeks. Under these conditions, slower changes in oxidation index (OI) occurred than those previously observed by aging at 60°C. Reduction of aging temperature below 60°C also changed the kinetics of oxidation such that the aldehyde peak (1732 cm−1) present at higher temperature was eliminated making the ketone/carboxylic acid region (1713–1718 cm−1) the primary region contributing to the calculation of the OIs for each group. The oxidation profiles obtained after 52 weeks at 40 and 50°C were consistent with retrievals that have undergone low oxidation, associated with maximum OI values of less than 1. Aging at 50°C represents a compromise between the slower oxidation rate of in vivo temperatures and the nonphysiological kinetics of elevated temperatures in an aqueous environment. However, even at 50°C over a year of in vitro aqueous aging will be necessary to reproduce the oxidation levels observed in long‐term implanted acetabular retrievals. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.31294