Extended release of a novel antidepressant, venlafaxine, based on anionic polyamidoamine dendrimers and poly(ethylene glycol)-containing semi-interpenetrating networks

The multiple daily administration of venlafaxine, a novel third‐generation antidepressant, was reduced based on polyamidoamine and polyethylene glycol (PEG)‐containing semi‐interpenetrating network (IPN), respectively. Venlafaxine was covalently linked to water‐soluble G2.5 anionic polyamidoamine de...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2005-01, Vol.72A (1), p.107-114
Main Authors: Yang, Hu, Lopina, Stephanie T.
Format: Article
Language:English
Subjects:
Acrylamide
Anions
Antidepressive Agents - administration & dosage
Cyclohexanols - administration & dosage
Delayed-Action Preparations - chemical synthesis
Delayed-Action Preparations - chemistry
extended release
Hydrogels - chemical synthesis
Hydrogels - chemistry
Magnetic Resonance Spectroscopy
Molecular Weight
Permeability
polyacrylamide hydrogel
Polyamines
polyethylene glycol
Polyethylene Glycols
semi-interpenetrating network (IPN)
Spectroscopy, Fourier Transform Infrared
Starburst® polyamidoamine (PAMAM) dendrimer
venlafaxine
Venlafaxine Hydrochloride
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Summary:The multiple daily administration of venlafaxine, a novel third‐generation antidepressant, was reduced based on polyamidoamine and polyethylene glycol (PEG)‐containing semi‐interpenetrating network (IPN), respectively. Venlafaxine was covalently linked to water‐soluble G2.5 anionic polyamidoamine dendrimer via a hydrolyzable ester bond. Semi‐IPN hydrogels were prepared by crosslinking acrylamide in the presence of PEG, and venlafaxine with predetermined amounts was loaded in situ. Dendrimer–venlafaxine conjugate and semi‐IPNs were characterized by proton nuclear magnetic resonance and Fourier transform infrared, respectively. The effect of PEG concentration and molecular weight was studied and discussed for an optimal controlled release. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 72A: 107–114, 2005
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30220