Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production

In Brazil, pomegranate ( Punica granatum L. (Punicaceae)) is widely used as a phytotherapeutic agent. This study evaluates the effect of pomegranate extract on Staphylococcus aureus FRI 722 growth and subsequent enterotoxin production. Bacterial susceptibility was determined by tube dilution method...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-01, Vol.96 (1), p.335-339
Main Authors: Braga, L.C., Shupp, J.W., Cummings, C., Jett, M., Takahashi, J.A., Carmo, L.S., Chartone-Souza, E., Nascimento, A.M.A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibacterial properties
Biological and medical sciences
Colony Count, Microbial
Dose-Response Relationship, Drug
enterotoxins
Enterotoxins - antagonists & inhibitors
Enterotoxins - biosynthesis
Fruit - chemistry
fruit extracts
General pharmacology
Medical sciences
medicinal plants
microbial growth
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
pomegranates
Punica granatum
Punicaceae
Staphylococcal enterotoxin A
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Time Factors
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Summary:In Brazil, pomegranate ( Punica granatum L. (Punicaceae)) is widely used as a phytotherapeutic agent. This study evaluates the effect of pomegranate extract on Staphylococcus aureus FRI 722 growth and subsequent enterotoxin production. Bacterial susceptibility was determined by tube dilution method and production of enterotoxin was assessed using membrane-over-agar (MOA) plates. At a low extract concentration (0.01% v/v) bacterial growth was delayed, while a higher concentration (1% v/v) eliminated bacterial growth. Most interestingly, a 0.05% (v/v) concentration of extract was found to inhibit Staphylococcal enterotoxin (SE) A production. These data further implicate pomegranate extracts as potential antibacterial therapeutics with the added ability to inhibit enterotoxin production.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2004.08.034