Absence of acute effects of angiotensin II on atrial electrophysiology in humans

In differing animal models, angiotensin-converting enzyme inhibition or angiotensin II (AII) antagonists has been shown to prevent both acute (hours) (2) electrical remodeling and chronic (weeks) structural remodeling (3). Clinical studies have suggested that AII antagonists or angiotensin-convertin...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2005-01, Vol.45 (1), p.154-156
Main Authors: Kistler, Peter M., Davidson, Neil C., Sanders, Prashanthan, Fynn, Simon P., Stevenson, Irene H., Spence, Steven J., Vohra, Jitendra K., Sparks, Paul B., Kalman, Jonathan M.
Format: Article
Language:English
Subjects:
Adult
Angiotensin II - pharmacology
Atrial Function - drug effects
Atrial Function - physiology
Cardiology
Drug therapy
Electrophysiologic Techniques, Cardiac
Enzymes
Female
Heart Atria - drug effects
Heart failure
Hemodynamics - drug effects
Humans
Male
Renin-Angiotensin System - physiology
Vasoconstrictor Agents - pharmacology
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Summary:In differing animal models, angiotensin-converting enzyme inhibition or angiotensin II (AII) antagonists has been shown to prevent both acute (hours) (2) electrical remodeling and chronic (weeks) structural remodeling (3). Clinical studies have suggested that AII antagonists or angiotensin-converting enzyme inhibitors may be effective in reducing AF in patients with heart failure or after cardioversion (10,11).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.10.002