New Synthesis of Benzothiazines and Benzoisothiazoles Containing a Sulfoximine Functional Group

The reaction of S-2-bromophenyl-S-methylsulfoximine with terminal alkynes in the presence of a palladium catalyst resulted in the formation of both 1,2-benzothiazines and 1,2-benzoisothiazoles. A preference for the former was seen with alkylalkynes, while the latter were preferentially formed with a...

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Bibliographic Details
Published in:Organic letters 2005-01, Vol.7 (1), p.143-145
Main Authors: Harmata, Michael, Rayanil, Kanok-on, Gomes, Maria G, Zheng, Pinguan, Calkins, Nathan L, Kim, Soo-Yeun, Fan, Yimin, Bumbu, Valentina, Lee, Dong Reyoul, Wacharasindhu, Sumrit, Hong, Xuechuan
Format: Article
Language:English
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Summary:The reaction of S-2-bromophenyl-S-methylsulfoximine with terminal alkynes in the presence of a palladium catalyst resulted in the formation of both 1,2-benzothiazines and 1,2-benzoisothiazoles. A preference for the former was seen with alkylalkynes, while the latter were preferentially formed with alkynylarenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol047781j