Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma

Cancer cachexia is a syndrome of weight loss, muscle wasting, fatigue, and anorexia that occurs in patients with advanced or recurrent solid tumor disease. Tumor necrosis factor‐alpha (TNFα) and prostaglandin E2 (PGE2) have been implicated in the biology of cachexia and serve as possible targets for...

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Bibliographic Details
Published in:Research in nursing & health 2005-02, Vol.28 (1), p.48-55
Main Authors: Graves, Erin, Hitt, Andrew, Pariza, Michael W., Cook, Mark E., McCarthy, Donna O.
Format: Article
Language:English
Subjects:
Adenocarcinoma - complications
Adenocarcinoma - pathology
Animals
Biological and medical sciences
Body Weight - drug effects
Cachexia - drug therapy
Cachexia - etiology
Cancer
cancer cachexia
colon-26 adenocarcinoma
Colonic Neoplasms - complications
Colonic Neoplasms - pathology
conjugated linoleic acid
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Fatty acids
Female
Linoleic Acids, Conjugated - pharmacology
Medical sciences
Mice
Miscellaneous
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Muscular system
Neoplasms, Experimental - complications
Neoplasms, Experimental - pathology
Nursing
Proteins
Public health. Hygiene
Public health. Hygiene-occupational medicine
Rodents
Tumor Cells, Cultured
tumor necrosis factor
Tumors
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Summary:Cancer cachexia is a syndrome of weight loss, muscle wasting, fatigue, and anorexia that occurs in patients with advanced or recurrent solid tumor disease. Tumor necrosis factor‐alpha (TNFα) and prostaglandin E2 (PGE2) have been implicated in the biology of cachexia and serve as possible targets for treatment of this condition. Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice. We hypothesized that a diet supplemented with .5% CLA might reduce muscle wasting in mice bearing the colon‐26 adenocarcinoma, an animal model of cancer cachexia. CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor‐bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle. © 2004 Wiley Periodicals, Inc. Res Nurs Health 28:48–55, 2005
ISSN:0160-6891
1098-240X
DOI:10.1002/nur.20052