Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities

• Published in: Bioorganic & medicinal chemistry letters 2009-07, Vol.19 (13), p.3389-3391
• Main Authors: Shou, Qing Yao, Tan, Qing, Shen, Zheng Wu
• Format: Article
• Language: English
• Subjects: B-Lymphocytes - drug effects; B-Lymphocytes - immunology; Biological and medical sciences; Campylotropis hirtella (Franch.) Schindl; Fabaceae - chemistry; General pharmacology; Hirtellanine A; Hirtellanine B; Immunosuppressive activity; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - isolation & purification; Immunosuppressive Agents - pharmacology; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Roots - chemistry; T-Lymphocytes - drug effects; T-Lymphocytes - immunology
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.05.043

A pair of isomeric isoflavonoid derivatives, Hirtellanines A ( 1) and B ( 2), has been isolated from the roots of Campylotropis hirtella. Hirtellanines A showed strong immunosuppressive activities. A pair of isomeric isoflavonoid derivatives, Hirtellanines A ( 1) and B ( 2), has been isolated from the roots of Campylotropis hirtella (Franch.) Schindl. and their structures were elucidated on the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques. The in vitro assay showed that Hirtellanine A had strong B lymphocyte suppression activity (IC 50: 0.06 μM) and T lymphocyte suppression activity (IC 50: 0.92 μM). Hirtellanine B showed moderate B lymphocyte suppression activity (IC 50: 3.00 μM) and T lymphocyte suppression activity (IC 50: 9.55 μM). Due to the potent immunosuppressive activities and lower cytotoxicity, Hirtellanine A could be a promising lead towards novel immunosuppressive agents.