A Protein's Final ESCRT

In eukaryotic cells, delivery of transmembrane proteins into the lumen of the lysosome for degradation is mediated by the multivesicular body pathway. The function of the ESCRT protein complexes is required for both the formation of multivesicular body lumenal vesicles and the sorting of endosomal c...

Full description

Saved in:
Bibliographic Details
Published in:Traffic (Copenhagen, Denmark) Denmark), 2005-01, Vol.6 (1), p.2-9
Main Author: Babst, Markus
Format: Article
Language:English
Subjects:
Animals
endosome
Endosomes - metabolism
ESCRT
Eukaryotic Cells - metabolism
Humans
lysosome
Lysosomes - metabolism
Models, Biological
multivesicular bodies
protein trafficking
Protein Transport - physiology
ubiquitin
Ubiquitin - genetics
Ubiquitin - metabolism
vacuole
Vacuoles - metabolism
Vesicular Transport Proteins - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In eukaryotic cells, delivery of transmembrane proteins into the lumen of the lysosome for degradation is mediated by the multivesicular body pathway. The function of the ESCRT protein complexes is required for both the formation of multivesicular body lumenal vesicles and the sorting of endosomal cargo proteins into these vesicles. Recent studies have identified additional factors that seem to function as an upstream cargo retention system feeding into the ESCRT machinery, given new insights into the dynamic structure of multivesicular bodies, and identified a potential mechanism for multivesicular body vesicle formation.
ISSN:1398-9219
1600-0854
DOI:10.1111/j.1600-0854.2004.00246.x