Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra)

The Brazilian medicinal plant Lychnophora ericoides Mart. (Asteraceae) has been used in traditional medicine to treat wounds, pain and inflammation. As part of our continuing investigation of this commercial phytomedicine, we focused on the polar fractions of the plant, since it is employed as alcoh...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-01, Vol.96 (3), p.545-549
Main Authors: dos Santos, Michel David, Gobbo-Neto, Leonardo, Albarella, Laura, de Souza, Glória Emília Petto, Lopes, Norberto Peporine
Format: Article
Language:English
Subjects:
Acetic Acid
Analgesic
analgesic effect
Animals
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arnica
Asteraceae
Biological and medical sciences
cyclohexanecarboxylic acids
Di-caffeoylquinic acids
Dose-Response Relationship, Drug
General pharmacology
Lychnophora
Lychnophora ericoides
Magnetic Resonance Spectroscopy
Medical sciences
medicinal plants
Mice
Monosaccharides - isolation & purification
Monosaccharides - therapeutic use
Pain - drug therapy
Pain Measurement
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant extracts
Plant Extracts - chemistry
Plant Extracts - therapeutic use
Plant Roots - chemistry
Quinic Acid - analogs & derivatives
Quinic Acid - isolation & purification
Quinic Acid - therapeutic use
Roots
traditional medicine
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Summary:The Brazilian medicinal plant Lychnophora ericoides Mart. (Asteraceae) has been used in traditional medicine to treat wounds, pain and inflammation. As part of our continuing investigation of this commercial phytomedicine, we focused on the polar fractions of the plant, since it is employed as alcoholic and hydroalcoholic preparations. The analgesic bioguided fractionation of the root polar extract yielded 3,5-di- O-[ E]-caffeoylquinic acid, 4,5-di- O-[ E]-caffeoylquinic acid and 3,4,5-tri- O-[ E]-caffeoylquinic acid. The n-butanol fraction and the di-caffeoylquinic acids showed significant analgesic activity in the acetic acid-induced mouse writhing test at low but not at high doses. These findings support, at least in part, the validity of the use of Lychnophora ericoides roots in traditional medicine.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2004.09.043