Stem cell plasticity

The central dogma in stem cell biology has been that cells isolated from a particular tissue can renew and differentiate into lineages of the tissue it resides in. Several studies have challenged this idea by demonstrating that tissue specific cell have considerable plasticity and can cross-lineage...

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Bibliographic Details
Published in:Blood reviews 2005, Vol.19 (1), p.29-38
Main Authors: Lakshmipathy, Uma, Verfaillie, Catherine
Format: Article
Language:English
Subjects:
Adult
Adult stem cells
Biological and medical sciences
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
Bone marrow-derived stem cells
Cell Differentiation - physiology
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - physiology
Humans
Mechanism of plasticity
Medical sciences
Organ-derived stem cells
Plasticity
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Summary:The central dogma in stem cell biology has been that cells isolated from a particular tissue can renew and differentiate into lineages of the tissue it resides in. Several studies have challenged this idea by demonstrating that tissue specific cell have considerable plasticity and can cross-lineage restriction boundary and give rise to cell types of other lineages. However, the lack of a clear definition for plasticity has led to confusion with several reports failing to demonstrate that a single cell can indeed differentiate into multiple lineages at significant levels. Further, differences between results obtained in different labs has cast doubt on some results and several studies still await independent confirmation. In this review, we critically evaluate studies that report stem cell plasticity using three rigid criteria to define stem cell plasticity; differentiation of a single cell into multiple cell lineages, functionality of differentiated cells in vitro and in vivo, robust and persistent engraft of transplanted cells.
ISSN:0268-960X
1532-1681
DOI:10.1016/j.blre.2004.03.001