Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation

Recurrent respiratory papillomatosis is the most common neoplasm of the larynx in childhood. Extension into lung parenchyma occurs in less than 1% of patients and has a low risk of malignant transformation. Treatment options for intrapulmonary spread have shown limited success. We describe a case of...

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Bibliographic Details
Published in:Pediatric pulmonology 2005-02, Vol.39 (2), p.185-188
Main Authors: Katz, Sherri L., Das, Prabodh, Ngan, Bo‐Yee, Manson, David, Pappo, Alberto S., Sweezey, Neil B., Solomon, Melinda P.
Format: Article
Language:English
Subjects:
adenosquamous carcinoma
Adolescent
Biological and medical sciences
Biopsy, Needle
Carcinoma, Adenosquamous - diagnostic imaging
Carcinoma, Adenosquamous - pathology
Carcinoma, Adenosquamous - therapy
Cell Transformation, Neoplastic - pathology
cidofovir
Combined Modality Therapy
Diagnosis, Differential
Female
Follow-Up Studies
human papilloma virus
Humans
Laryngeal Neoplasms - diagnostic imaging
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - therapy
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung Neoplasms - therapy
malignant transformation
Medical sciences
Neoplasm Recurrence, Local - pathology
Papilloma - diagnostic imaging
Papilloma - pathology
Papilloma - therapy
Pneumology
pulmonary nodules
pulmonary parenchymal involvement
Radiography, Thoracic
recurrent respiratory papillomatosis
Tomography, X-Ray Computed
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Description
Summary:Recurrent respiratory papillomatosis is the most common neoplasm of the larynx in childhood. Extension into lung parenchyma occurs in less than 1% of patients and has a low risk of malignant transformation. Treatment options for intrapulmonary spread have shown limited success. We describe a case of recurrent respiratory papillomatosis with extensive parenchymal involvement and adenosquamous carcinoma in a 14‐year‐old girl. © 2004 Wiley‐Liss, Inc.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.20116