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Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry

Objectives  To establish whether reagent‐supported thrombelastometry with the rotation thrombelastometry system (ROTEM®) point‐of‐care device correlated with fibrinogen level in postpartum haemorrhages. Design  Prospective observational study. Population and setting  Ninety‐one women at the third tr...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2009-07, Vol.116 (8), p.1097-1102
Main Authors: Huissoud, C, Carrabin, N, Audibert, F, Levrat, A, Massignon, D, Berland, M, Rudigoz, R‐C
Format: Article
Language:English
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Summary:Objectives  To establish whether reagent‐supported thrombelastometry with the rotation thrombelastometry system (ROTEM®) point‐of‐care device correlated with fibrinogen level in postpartum haemorrhages. Design  Prospective observational study. Population and setting  Ninety‐one women at the third trimester of pregnancy: 37 with postpartum haemorrhage (study group) and 54 without abnormal bleeding (control group). Methods  Standard laboratory test results were compared with those obtained at bedside from the ROTEM with the FIBTEM® test (54 tests in the control group and 51 in the study group). Main outcome measures  Analysis of correlations between fibrinogen levels and FIBTEM test results: clotting time (CT), clot amplitude at 5 and 15 minutes (CA5; CA15) and maximal amplitude [maximum clot firmness (MCF)]. Results  Median fibrinogen level was significantly lower in the haemorrhage group than in the control group (3.4 and 5.1 g/l, respectively, P 
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2009.02187.x