Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson’s disease

Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in P...

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Bibliographic Details
Published in:Neurogenetics 2009-07, Vol.10 (3), p.173-181
Main Authors: González-Pérez, A., Gayán, J., Marín, J., Galán, J. J., Sáez, M. E., Real, L. M., Antúnez, C., Ruiz, A.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Databases, Genetic
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Epistasis, Genetic
Fundamental and applied biological sciences. Psychology
Genetic Markers
Genetic Predisposition to Disease
Genetics of eukaryotes. Biological and molecular evolution
Genome
Genome-Wide Association Study
Genomics
Human Genetics
Humans
Medical sciences
Middle Aged
Molecular and cellular biology
Molecular Medicine
Molecular Sequence Data
Neurology
Neurosciences
Original Article
Parkinson Disease - epidemiology
Parkinson Disease - genetics
Parkinson's disease
Polymorphism
Polymorphism, Single Nucleotide
Vertebrates: nervous system and sense organs
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Summary:Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson’s disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.
ISSN:1364-6745
1364-6753
DOI:10.1007/s10048-009-0170-8