Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23)

• Published in: Cancer genetics and cytogenetics 2005, Vol.156 (1), p.49-53
• Main Authors: Fujiwara, Tohru, Ichinohasama, Ryo, Miura, Ikuo, Sugawara, Tomohiro, Harigae, Hideo, Yokoyama, Hisayuki, Takahashi, Shinichiro, Tomiya, Yasuo, Yamada, Minami, Ishizawa, Kenichi, Kameoka, Junichi, Sasaki, Takeshi
• Format: Article
• Language: English
• Subjects: Aged; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 22; Epstein-Barr virus; Female; Hepatitis C virus; Herpesvirus; Human herpesvirus 8; Human immunodeficiency virus; Humans; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - pathology; Pleural Effusion, Malignant - etiology; Pleural Effusion, Malignant - genetics; Spectral Karyotyping; Translocation, Genetic
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/j.cancergencyto.2004.04.013

We report a case of primary effusion lymphoma (PEL) in a 75-year-old woman without human immunodeficiency virus or hepatitis C virus, which presented as fever, chest pain, and pericardial effusion. The lymphoma cells were positive for CD20 and CD79a, and were negative for CD3 and CD10. Genomic human herpes virus 8 (HHV-8) and Epstein-Barr virus were not detected in the lymphoma cells. Cytogenetic analysis showed complex abnormalities by the G-banding technique, and spectral karyotyping (SKY) analysis provided more detailed characterization of the chromosomal aberrations, including t(1;22)(q21;q11) and t(14;17)(q32;q23). We did not detect C-MYC gene rearrangement or BCL-2 expression. She was treated successfully with six courses of the CHOP regimen. The present case demonstrated a rare category of PEL that is not associated with HHV-8 or C-MYC gene rearrangement. In addition, SKY analysis disclosed cryptic chromosomal abnormalities involving 1q21 and 17q23.