Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary

Cytogenetic analysis of a case of metastatic granulosa cell tumor recurring 21 years after oophorectomy revealed monosomy 22. This anomaly, typical of granulosa cell tumor, coupled with the pathologic and immunophenotypic findings assisted in establishing the proper diagnosis of this lesion in the a...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2005, Vol.156 (1), p.83-85
Main Authors: Caughron, Samuel K., Bridge, Julia A., Bewtra, Chhanda B., Hunter, William J., Nelson, Marilu, Soundararajan, Suganthi, Silva, Edibaldo, Gatalica, Zoran
Format: Article
Language:English
Subjects:
Aged
Chromosomes, Human, Pair 22
Female
Granulosa Cell Tumor - genetics
Granulosa Cell Tumor - pathology
Humans
Karyotyping
Monosomy
Ovarian Neoplasms - genetics
Retroperitoneal Neoplasms - genetics
Retroperitoneal Neoplasms - pathology
Retroperitoneal Neoplasms - secondary
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Summary:Cytogenetic analysis of a case of metastatic granulosa cell tumor recurring 21 years after oophorectomy revealed monosomy 22. This anomaly, typical of granulosa cell tumor, coupled with the pathologic and immunophenotypic findings assisted in establishing the proper diagnosis of this lesion in the absence of the original histopathologic slides.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2004.04.025