Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility

Within mitochondria, manganese superoxide dismutase )MnSOD) provides a major defence against oxidative damage by reactive oxygen species )ROS). An alanine‐9valine )Ala‐9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of...

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Bibliographic Details
Published in:Cell biochemistry and function 2005-01, Vol.23 (1), p.73-76
Main Authors: Kocabaş, Neslihan Aygün, Şardaş, Semra, Cholerton, Suzanne, Daly, Ann K., Elhan, Atilla H., Karakaya, Ali Esat
Format: Article
Language:English
Subjects:
Alleles
breast cancer
Breast Neoplasms - enzymology
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Case-Control Studies
DNA - genetics
Female
free radical
Gene Frequency - genetics
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
MnSOD genetic polymorphism
Odds Ratio
oestrogen
Polymorphism, Genetic
Superoxide Dismutase - genetics
Turkey - epidemiology
Turkish population
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Summary:Within mitochondria, manganese superoxide dismutase )MnSOD) provides a major defence against oxidative damage by reactive oxygen species )ROS). An alanine‐9valine )Ala‐9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case–control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala‐9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction–restriction fragment length polymorphism )PCR‐RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio )OR): 0.86 )95% confidence interval )CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O‐methyltransferase COMT‐L )V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index )BMI) greater than 24 kg m−2 )OR: 1.42 )95%CI=1.04–1.93)). Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1128