Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study

• Published in: Mechanisms of ageing and development 2005-02, Vol.126 (2), p.333-339
• Main Authors: Stessman, Jochanan, Maaravi, Yoram, Hammerman-Rozenberg, Robert, Cohen, Aaron, Nemanov, Lubov, Gritsenko, Inga, Gruberman, Nelly, Ebstein, Richard P.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aging; Aging - ethnology; Aging - genetics; Angiotensinogen; Angiotensinogen - genetics; Apolipoprotein E; Apolipoproteins E - genetics; Biological and medical sciences; Cathepsin D; Cathepsin D - genetics; Development. Metamorphosis. Moult. Ageing; DNA Primers - genetics; Dopamine D4 receptor; Factor VII - genetics; Female; Fundamental and applied biological sciences. Psychology; Genes, p53 - genetics; Genetic Linkage; Genotype; Humans; IGF2; Insulin - metabolism; Insulin-Like Growth Factor II - genetics; Israel; Leiden factors V and VII; Life Expectancy; Longevity; Longevity - genetics; Longitudinal Studies; Male; Membrane Glycoproteins - genetics; Membrane Transport Proteins - genetics; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Nerve Tissue Proteins - genetics; Polymorphism, Genetic; Polymorphisms; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D4; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Serotonin transporter; Superoxide dismutase; Superoxide Dismutase - genetics; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/j.mad.2004.08.025

In an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein E (apoE), methylenetetrahydrofolate reductase (MTHFR), cathepsin D (CAD), superoxide dismutase 2 (SOD2), angiotensinogen (AGT) and insulin-like growth factor 2 (IGF2), Leiden factor 7, p53 oncogene, dopamine D4 receptor (DRD4) and the serotonin transporter (SERT). Genotype and allele frequencies of these genes were compared in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity to a group of 441 younger subjects (22 years). Nominally significant results provide suggestive evidence in the Ashkenazi group that apoE, MHTFR, SOD2, IGF2 ApaI, and factor VII are risk factors for a single outcome, survival to 75. Overall, the more genetically homogenous Ashkenazi ethnic group showed evidence for association in five genes examined suggesting that future studies in this population would gainfully focus on this ethnic group.