Surgical removal of primary central nervous system lymphomas (PCNSL) presenting as space occupying lesions: a series of 33 cases

In this study we present a series of 33 patients with primary CNS lymphomas (PCNSL), many presenting with acute signs of increased intracranial pressure due to large space occupying lesions. A series of 32 PCNSL patients for a total of 33 tumours treated from 1986 to 2000 in the Neurosurgical Depart...

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Bibliographic Details
Published in:European journal of surgical oncology 2005-02, Vol.31 (1), p.100-105
Main Authors: Bellinzona, M., Roser, F., Ostertag, H., Gaab, R.M., Saini, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Brain neoplasm
Central Nervous System Neoplasms - drug therapy
Central Nervous System Neoplasms - radiotherapy
Central Nervous System Neoplasms - surgery
Combined Modality Therapy
Female
Humans
Immunohistochemistry
In Situ Nick-End Labeling
Ki-67
Lymphoma
Lymphoma, B-Cell - drug therapy
Lymphoma, B-Cell - radiotherapy
Lymphoma, B-Cell - surgery
Lymphoma, T-Cell - drug therapy
Lymphoma, T-Cell - radiotherapy
Lymphoma, T-Cell - surgery
Male
Middle Aged
Proportional Hazards Models
Statistics, Nonparametric
Survival
Treatment Outcome
Vascularity
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Summary:In this study we present a series of 33 patients with primary CNS lymphomas (PCNSL), many presenting with acute signs of increased intracranial pressure due to large space occupying lesions. A series of 32 PCNSL patients for a total of 33 tumours treated from 1986 to 2000 in the Neurosurgical Department were reviewed. Radiotherapy and chemotherapy improved survival. No benefit could be demonstrated for the role of surgery. Our data confirm previous reports about the role of radiation and chemotherapy in the treatment of PCNSL's. Surgery might have a role in a selected subset of patients presenting with large single space occupying lesions and deteriorating neurological status.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2004.10.002