Bone infection in patients suspected of complicating osteomyelitis: the diagnostic value of dual isotope bone-granulocyte scintigraphy

Summary Aim:  The purpose of this study was to evaluate the diagnostic value of dual isotope bone‐granulocyte scintigraphy in patients with known bone pathology clinically suspected of osteomyelitis, i.e. complicating osteomyelitis, using per‐operative bacterial culture from bone as reference. Metho...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2005-01, Vol.25 (1), p.20-26
Main Authors: Buhl, Thora, Stentzer, Kim, Hede, Adam, Kjær, Andreas, Hesse, Birger
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Sedimentation
bone-granulocyte scintigraphy
C-Reactive Protein - analysis
Diagnosis, Differential
dual isotope
Female
Granulocytes - diagnostic imaging
Granulocytes - microbiology
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Osteoarticular system. Muscles
osteomyelitis
Osteomyelitis - complications
Osteomyelitis - diagnosis
Osteomyelitis - microbiology
Predictive Value of Tests
Radiography
Radionuclide Imaging
Radionuclide investigations
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Sodium Pertechnetate Tc 99m
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Summary:Summary Aim:  The purpose of this study was to evaluate the diagnostic value of dual isotope bone‐granulocyte scintigraphy in patients with known bone pathology clinically suspected of osteomyelitis, i.e. complicating osteomyelitis, using per‐operative bacterial culture from bone as reference. Methods:  Simultaneous dual isotope bone‐granulocyte scintigraphic images were obtained in 42 consecutive patients in whom conventional X‐ray, erythrocyte sedimentation rate, and C‐reactive protein were also available. 99mTc MDP bone and 111In labelled granulocyte imaging was obtained simultaneously. The images were interpreted as positive for osteomyelitis if regions of interests of pathologic 111In granulocyte accumulation included 99mTc MDP activity on the bone images (except in the spine). Results:  The sensitivity, specificity, and accuracy were 84, 71 and 79%, respectively, for simultaneous, dual isotope bone‐granulocyte scintigraphy, higher than the other diagnostic parameters. Conclusion:  Simultaneous bone‐granulocyte scintigraphy is a valuable diagnostic tool in diagnosing osteomyelitis complicating other bone pathology with or without soft‐tissue infection.
ISSN:1475-0961
1475-097X
DOI:10.1111/j.1475-097X.2004.00581.x