Altered ghrelin and peptide YY responses to meals in bulimia nervosa

Summary Objective  In recent years great advances have been made in our understanding of the peripheral signals produced within the gastrointestinal tract that regulate appetite, such as ghrelin and peptide YY (PYY). While ghrelin elicites hunger signals, PYY elicites satiety. Therefore, alterations...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2005-01, Vol.62 (1), p.74-78
Main Authors: Kojima, Shinya, Nakahara, Toshihiro, Nagai, Nobuatsu, Muranaga, Tetsuro, Tanaka, Muneki, Yasuhara, Daisuke, Masuda, Akinori, Date, Yukari, Ueno, Hiroaki, Nakazato, Masamitsu, Naruo, Tetsuro
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Blood Glucose - analysis
Bulimia - blood
Case-Control Studies
Eating - physiology
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Ghrelin
Humans
Insulin - blood
Medical sciences
Peptide Hormones - blood
Peptide YY - blood
Postprandial Period
Vertebrates: endocrinology
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Summary:Summary Objective  In recent years great advances have been made in our understanding of the peripheral signals produced within the gastrointestinal tract that regulate appetite, such as ghrelin and peptide YY (PYY). While ghrelin elicites hunger signals, PYY elicites satiety. Therefore, alterations in hormone physiology may play a role in the pathogenesis of bulimia nervosa (BN). In this study, we investigated the postprandial profile of ghrelin and PYY levels in patients with BN. Design and patients  Postprandial plasma ghrelin and PYY levels and insulin and glucose responses were measured in 10 patients with BN and 12 control patients in response to a standard 400 kcal meal. Results  Basal ghrelin levels present in BN subjects (265·0 ± 25·5 pmol/l) were significantly higher than those in healthy controls (199·3 ± 18·4 pmol/l, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2004.02176.x