Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway

• Published in: Journal of Virology 2009-07, Vol.83 (13), p.6739-6747
• Main Authors: Lee, Hye-Ra, Toth, Zsolt, Shin, Young C, Lee, Jong-Soo, Chang, Heesoon, Gu, Wei, Oh, Tae-Kwang, Kim, Myung Hee, Jung, Jae U
• Format: Article
• Language: English
• Subjects: Apoptosis; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Line; Cellular Response to Infection; Down-Regulation; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - metabolism; Human herpesvirus 8; Humans; Interferon Regulatory Factors - metabolism; Kaposi's sarcoma-associated herpesvirus; Medical sciences; Microbiology; Proto-Oncogene Proteins c-mdm2 - metabolism; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Repressor Proteins - metabolism; Tumor Suppressor Protein p53 - metabolism; Tumors; Ubiquitination; Viral Proteins - metabolism; Virology; Viruses
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.02353-08

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