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Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology
Summary The aim of this randomised, double‐blind study was to investigate the usefulness of intravenous nefopam, clonidine or placebo in preventing shivering in patients undergoing conscious sedation for interventional neuroradiological procedures. A total of 101 patients were prospectively enrolled...
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| Published in: | Anaesthesia 2005-02, Vol.60 (2), p.124-128 |
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| container_end_page | 128 |
| container_issue | 2 |
| container_start_page | 124 |
| container_title | Anaesthesia |
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| creator | Bilotta, F. Ferri, F. Giovannini, F. Pinto, G. Rosa, G. |
| description | Summary
The aim of this randomised, double‐blind study was to investigate the usefulness of intravenous nefopam, clonidine or placebo in preventing shivering in patients undergoing conscious sedation for interventional neuroradiological procedures. A total of 101 patients were prospectively enrolled and assigned to one of three groups to receive nefopam, clonidine or placebo. The overall incidence of intra‐operative shivering was significantly lower in patients treated with nefopam than in those treated with clonidine or placebo (2/32 (6%) vs. 11/38 (29%), p |
| doi_str_mv | 10.1111/j.1365-2044.2004.04032.x |
| format | article |
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The aim of this randomised, double‐blind study was to investigate the usefulness of intravenous nefopam, clonidine or placebo in preventing shivering in patients undergoing conscious sedation for interventional neuroradiological procedures. A total of 101 patients were prospectively enrolled and assigned to one of three groups to receive nefopam, clonidine or placebo. The overall incidence of intra‐operative shivering was significantly lower in patients treated with nefopam than in those treated with clonidine or placebo (2/32 (6%) vs. 11/38 (29%), p < 0.02; 2/32 (6%) vs. 24/31 (77%), p < 0.0001, respectively). The number of patients who required ephedrine infusions to maintain a mean arterial pressure of 100 mm Hg was higher in the clonidine group than in the nefopam and placebo groups (18/38 (47%) vs. 5/32 (17%), p < 0.05; 18/38 (47%) vs. 6/31 (19%), p < 0.05, respectively). We found that both nefopam and clonidine significantly lowered the rate and severity of shivering during interventional neuroradiological procedures. Fewer patients in the nefopam group than in the other two groups required vasoactive drugs.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2004.04032.x</identifier><identifier>PMID: 15644007</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Analgesics - pharmacology ; Analgesics, Non-Narcotic - pharmacology ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Pressure ; Clonidine - pharmacology ; Conscious Sedation - adverse effects ; Double-Blind Method ; Ephedrine - administration & dosage ; Female ; Heart Rate ; Humans ; Male ; Medical sciences ; Middle Aged ; Nefopam - pharmacology ; Neurology ; Neuroradiography ; Pharmacology ; Prospective Studies ; Radiology, Interventional ; Severity of Illness Index ; Shivering - drug effects ; Shivering - physiology ; Vasoconstrictor Agents - administration & dosage</subject><ispartof>Anaesthesia, 2005-02, Vol.60 (2), p.124-128</ispartof><rights>2005 INIST-CNRS</rights><rights>2005 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5062-cafa604616c51ab42290ece9d795eb4ca90379060d3726d342efc73fcdff449c3</citedby><cites>FETCH-LOGICAL-c5062-cafa604616c51ab42290ece9d795eb4ca90379060d3726d342efc73fcdff449c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16518817$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15644007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilotta, F.</creatorcontrib><creatorcontrib>Ferri, F.</creatorcontrib><creatorcontrib>Giovannini, F.</creatorcontrib><creatorcontrib>Pinto, G.</creatorcontrib><creatorcontrib>Rosa, G.</creatorcontrib><title>Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
The aim of this randomised, double‐blind study was to investigate the usefulness of intravenous nefopam, clonidine or placebo in preventing shivering in patients undergoing conscious sedation for interventional neuroradiological procedures. A total of 101 patients were prospectively enrolled and assigned to one of three groups to receive nefopam, clonidine or placebo. The overall incidence of intra‐operative shivering was significantly lower in patients treated with nefopam than in those treated with clonidine or placebo (2/32 (6%) vs. 11/38 (29%), p < 0.02; 2/32 (6%) vs. 24/31 (77%), p < 0.0001, respectively). The number of patients who required ephedrine infusions to maintain a mean arterial pressure of 100 mm Hg was higher in the clonidine group than in the nefopam and placebo groups (18/38 (47%) vs. 5/32 (17%), p < 0.05; 18/38 (47%) vs. 6/31 (19%), p < 0.05, respectively). We found that both nefopam and clonidine significantly lowered the rate and severity of shivering during interventional neuroradiological procedures. Fewer patients in the nefopam group than in the other two groups required vasoactive drugs.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Clonidine - pharmacology</subject><subject>Conscious Sedation - adverse effects</subject><subject>Double-Blind Method</subject><subject>Ephedrine - administration & dosage</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nefopam - pharmacology</subject><subject>Neurology</subject><subject>Neuroradiography</subject><subject>Pharmacology</subject><subject>Prospective Studies</subject><subject>Radiology, Interventional</subject><subject>Severity of Illness Index</subject><subject>Shivering - drug effects</subject><subject>Shivering - physiology</subject><subject>Vasoconstrictor Agents - administration & dosage</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkd1u1DAQhSMEokvhFZCFBHcJ4584yQ3Sqio_UlVu4NryOuNdr7J2sDel-xC8M3E3ohI34BtbM9-cOdYpCkKhovN5v68ol3XJQIiKAYgKBHBW3T8pVn8aT4sVAPCSCeguihcp7QEoa2n7vLigtRQCoFkVv27RhlEfSIjEDMG73nkkzpPjDsm40_GgTRjC1hkyRrxDf3TBk2BJ2rk7jM5vMzzqo5tbiUy-x7gNuWyCT8aFKZGEvX4Ys_MS548YFx09EI9TDFH3Li85vSyeWT0kfLXcl8X3j9ffrj6XN18_fbla35SmBslKo62WICSVpqZ6IxjrAA12fdPVuBFGd8CbDiT0vGGy54KhNQ23prdWiM7wy-LdWXeM4ceE6agOLhkcBu1xdqxkw-uWcvFPkHY1bduGzeCbv8B9mOL8w8zMakLWMEPtGTIxpBTRqjG6g44nRUHlYNVe5fxUzk_lYNVDsOp-Hn296E-bA_aPg0uSM_B2AXQyerBRe-PSIyezUZq5D2fupxvw9N8G1Pp2fZ2f_DesN8HP</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Bilotta, F.</creator><creator>Ferri, F.</creator><creator>Giovannini, F.</creator><creator>Pinto, G.</creator><creator>Rosa, G.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology</title><author>Bilotta, F. ; Ferri, F. ; Giovannini, F. ; Pinto, G. ; Rosa, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5062-cafa604616c51ab42290ece9d795eb4ca90379060d3726d342efc73fcdff449c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Clonidine - pharmacology</topic><topic>Conscious Sedation - adverse effects</topic><topic>Double-Blind Method</topic><topic>Ephedrine - administration & dosage</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nefopam - pharmacology</topic><topic>Neurology</topic><topic>Neuroradiography</topic><topic>Pharmacology</topic><topic>Prospective Studies</topic><topic>Radiology, Interventional</topic><topic>Severity of Illness Index</topic><topic>Shivering - drug effects</topic><topic>Shivering - physiology</topic><topic>Vasoconstrictor Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilotta, F.</creatorcontrib><creatorcontrib>Ferri, F.</creatorcontrib><creatorcontrib>Giovannini, F.</creatorcontrib><creatorcontrib>Pinto, G.</creatorcontrib><creatorcontrib>Rosa, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilotta, F.</au><au>Ferri, F.</au><au>Giovannini, F.</au><au>Pinto, G.</au><au>Rosa, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2005-02</date><risdate>2005</risdate><volume>60</volume><issue>2</issue><spage>124</spage><epage>128</epage><pages>124-128</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
The aim of this randomised, double‐blind study was to investigate the usefulness of intravenous nefopam, clonidine or placebo in preventing shivering in patients undergoing conscious sedation for interventional neuroradiological procedures. A total of 101 patients were prospectively enrolled and assigned to one of three groups to receive nefopam, clonidine or placebo. The overall incidence of intra‐operative shivering was significantly lower in patients treated with nefopam than in those treated with clonidine or placebo (2/32 (6%) vs. 11/38 (29%), p < 0.02; 2/32 (6%) vs. 24/31 (77%), p < 0.0001, respectively). The number of patients who required ephedrine infusions to maintain a mean arterial pressure of 100 mm Hg was higher in the clonidine group than in the nefopam and placebo groups (18/38 (47%) vs. 5/32 (17%), p < 0.05; 18/38 (47%) vs. 6/31 (19%), p < 0.05, respectively). We found that both nefopam and clonidine significantly lowered the rate and severity of shivering during interventional neuroradiological procedures. Fewer patients in the nefopam group than in the other two groups required vasoactive drugs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15644007</pmid><doi>10.1111/j.1365-2044.2004.04032.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anaesthesia, 2005-02, Vol.60 (2), p.124-128 |
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| source | Wiley |
| subjects | Adult Aged Analgesics - pharmacology Analgesics, Non-Narcotic - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Pressure Clonidine - pharmacology Conscious Sedation - adverse effects Double-Blind Method Ephedrine - administration & dosage Female Heart Rate Humans Male Medical sciences Middle Aged Nefopam - pharmacology Neurology Neuroradiography Pharmacology Prospective Studies Radiology, Interventional Severity of Illness Index Shivering - drug effects Shivering - physiology Vasoconstrictor Agents - administration & dosage |
| title | Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology |
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