Lack of evidence for mu-opioid regulation of a socially mediated separation response

Maternal potentiation of ultrasonic vocalization (USV) occurs when, after a brief contact with the dam, reisolated infant rats produce USV at a rate as much as double or triple their calling rate in the initial isolation. Potentiation occurs most robustly when the dam is alert (active) but is also e...

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Bibliographic Details
Published in:Physiology & behavior 2005-01, Vol.83 (5), p.767-777
Main Authors: Shair, Harry N., Brunelli, Susan A., Hofer, Myron A.
Format: Article
Language:English
Subjects:
Affiliation
Animal ethology
Animals
Attachment
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Female
Fundamental and applied biological sciences. Psychology
Isolation
Male
Mammalia
Maternal Deprivation
Maternal potentiation
Morphine
Morphine - pharmacology
Naltrexone
Naltrexone - pharmacology
Narcotic Antagonists - pharmacology
Narcotics - pharmacology
Neurotransmission and behavior
Opioids
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Receptors, Opioid, mu - agonists
Receptors, Opioid, mu - antagonists & inhibitors
Receptors, Opioid, mu - physiology
Separation response
Social Environment
Social Isolation
Ultrasonic vocalization
Ultrasonics
Vertebrata
Vocalization, Animal
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Description
Summary:Maternal potentiation of ultrasonic vocalization (USV) occurs when, after a brief contact with the dam, reisolated infant rats produce USV at a rate as much as double or triple their calling rate in the initial isolation. Potentiation occurs most robustly when the dam is alert (active) but is also elicited by an anesthetized dam (passive). The possible role of μ-opioid receptors in control of both active and passive potentiation was tested using the μ-preferring receptor agonist morphine and antagonist naltrexone. While high levels of morphine did suppress USV rate in both the initial and the second isolation, neither agonist nor antagonist demonstrated an effect specific to potentiation. That is, no dose of morphine or naltrexone suppressed or enhanced the response to the active dam, and only the highest dose of morphine prevented potentiation with the passive dam. The results do not support the possibility that activation of μ-receptors by endogenous opioids regulates the increase in USV caused by maternal potentiation.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2004.09.019