Genetic Abnormalities among Severely Oligospermic Men Who Are Candidates for Intracytoplasmic Sperm Injection

Recent reports suggest that children born after intracytoplasmic sperm injection performed for male factor infertility are at increased risk of congenital malformations and chromosome aberrations. To explain these observations, we hypothesized that infertile men may be more likely than fertile men t...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2005-01, Vol.90 (1), p.152-156
Main Authors: Foresta, Carlo, Garolla, Andrea, Bartoloni, Lucia, Bettella, Andrea, Ferlin, Alberto
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Aberrations
Chromosomes, Human, Y
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Endocrinopathies
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Oligospermia - genetics
Sperm Injections, Intracytoplasmic
Spermatozoa - ultrastructure
Vertebrates: endocrinology
Citations: Items that cite this one
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Summary:Recent reports suggest that children born after intracytoplasmic sperm injection performed for male factor infertility are at increased risk of congenital malformations and chromosome aberrations. To explain these observations, we hypothesized that infertile men may be more likely than fertile men to have genetic abnormalities. We studied 750 severely oligozoospermic men (sperm count
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2004-1469