Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology

Recent studies on mice with surgically induced acute myocardial infarction (AMI) have documented the frequent occurrence of ventricular rupture, an event not previously reported in other laboratory species. We have examined the natural history, histopathology and myocardial mechanical strength in mi...

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Bibliographic Details
Published in:Cardiovascular research 2005-02, Vol.65 (2), p.469-477
Main Authors: GAO, Xiao-Ming, QI XU, KIRIAZIS, Helen, DART, Anthony M, DU, Xiao-Jun
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Female
Gender Identity
Heart
Heart Rupture, Post-Infarction - pathology
Male
Medical sciences
Mice
Mice, Inbred Strains
Models, Animal
Myocardial Infarction - pathology
Myocarditis. Cardiomyopathies
Myocardium - pathology
Species Specificity
Tensile Strength
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Summary:Recent studies on mice with surgically induced acute myocardial infarction (AMI) have documented the frequent occurrence of ventricular rupture, an event not previously reported in other laboratory species. We have examined the natural history, histopathology and myocardial mechanical strength in mice with AMI. AMI was induced by coronary artery occlusion and animals were monitored for fatal events. Gross and histological examinations were undertaken. Rupture occurred in the left ventricular free wall at 2-6 days after AMI. Incidence of rupture in male mice varied among three strains studied (3% for FVB/N, 27% for C57B/6J, and 59% for 129sv, P
ISSN:0008-6363
1755-3245
DOI:10.1016/j.cardiores.2004.10.014