Markers of Coagulation Activation, Endothelial Stimulation and Inflammation in Patients with Peripheral Arterial Disease

Patients with peripheral arterial disease have a significantly increased risk of cardiovascular and cerebrovascular mortality. Studies have shown that some haemostatic and inflammatory markers are elevated in these patients but the effect of the severity of the disease has not been fully documented....

Full description

Saved in:
Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2005-02, Vol.29 (2), p.171-176
Main Authors: Cassar, K., Bachoo, P., Ford, I., Greaves, M., Brittenden, J.
Format: Article
Language:English
Subjects:
Aged
Antithrombin III
Biomarkers - blood
C-Reactive Protein - analysis
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Fibrin Fibrinogen Degradation Products - analysis
Haemostasis
Humans
Inflammation - blood
Intermittent Claudication - blood
Ischemia - blood
Leg - blood supply
Male
Middle Aged
Peptide Hydrolases - blood
Peripheral arterial disease
Prospective Studies
Thrombosis and vascular biology
von Willebrand Factor - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients with peripheral arterial disease have a significantly increased risk of cardiovascular and cerebrovascular mortality. Studies have shown that some haemostatic and inflammatory markers are elevated in these patients but the effect of the severity of the disease has not been fully documented. The aim of this study was to assess the level of coagulation activation, endothelial stimulation and inflammation in patients with claudication and critical limb ischaemia (CLI) compared to healthy controls. A prospective observational study was conducted amongst 202 subjects: 132 claudicants, 30 patients with critical ischaemia, and 40 controls. D-dimer (DD) and thrombin–antithrombin III (TAT) levels measured using ELISA as markers of coagulation activation. von Willebrand factor (vWF) and high-sensitivity C-reactive protein (CRP) levels were measured as markers of endothelial and inflammatory stimulation. vWF and CRP levels were significantly higher in patients with intermittent claudication (1.9 U/ml, range 0.78–4.05; p0.001, respectively) and critical ischaemia (2.36 U/ml; range 1.03–5.69; p
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2004.11.001