Immediate hypersensitivity to Malassezia furfur and Candida albicans mannans in vivo and in vitro

Background:  Elevated and correlative Malassezia furfur (M. furfur) and Candida albicans (C. albicans) mannan‐specific IgE have been demonstrated in atopic eczema dermatitis syndrome (AEDS) of the head, neck and shoulder (HNS) region of the skin. The significance of these antibodies in vivo has not...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2005-02, Vol.60 (2), p.238-242
Main Authors: Kosonen, J., Lintu, P., Kortekangas‐Savolainen, O., Kalimo, K., Terho, E. O., Savolainen, J.
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Allergies
Antigens
atopic eczema dermatitis syndrome
Biological and medical sciences
Candida albicans
Candida albicans - immunology
Dermatitis
Dermatitis, Atopic - immunology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Hypersensitivity, Immediate - diagnosis
Hypersensitivity, Immediate - immunology
IgE
Immunoglobulin E - metabolism
Immunopathology
In Vitro Techniques
Malassezia - immunology
Malassezia furfur
Male
mannan
Mannans - immunology
Medical sciences
Medical screening
Skin allergic diseases. Stinging insect allergies
skin prick test
Skin Tests
Yeast
Yeasts - immunology
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Summary:Background:  Elevated and correlative Malassezia furfur (M. furfur) and Candida albicans (C. albicans) mannan‐specific IgE have been demonstrated in atopic eczema dermatitis syndrome (AEDS) of the head, neck and shoulder (HNS) region of the skin. The significance of these antibodies in vivo has not been demonstrated. Methods:  Sixty‐five AEDS patients with HNS distribution were included. Serum total IgE (S‐IgE) and yeast antigen‐specific (Cetavlon‐purified mannan and whole extract antigens of M. furfur and C. albicans) IgE were measured and skin prick tests (SPT) were performed with the yeast antigens. Results:  Mannan‐specific IgE and SPT were positive in 51 and 48% of patients with M. furfur and in 42 and 22% with C. albicans, respectively. Whole extract‐specific IgE and SPT were positive in 85 and 95% of patients with M. furfur and in 91 and 57% with C. albicans, respectively. The highest correlation between specific IgE and SPT was seen with M. furfur mannan (r = 0.60; P 
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2005.00686.x