Ghrelin and adiponectin in patients with Cushing's disease before and after successful transsphenoidal surgery

Summary background  Ghrelin, an endogenous ligand of the GH secretagogue receptor that exerts orexigenic activity, is negatively correlated with body mass index (BMI) and insulin resistance. Conversely, low levels of adiponectin (ApN), a circulating adipocytokine with antidiabetic, antiatherogenic a...

Full description

Saved in:
Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2005-01, Vol.62 (1), p.30-36
Main Authors: Libè, Rossella, Morpurgo, Paola Silvia, Cappiello, Vincenzo, Maffini, Antonia, Bondioni, Sara, Locatelli, Marco, Zavanone, Mario, Beck-Peccoz, Paolo, Spada, Anna
Format: Article
Language:English
Subjects:
Acute Disease
Adiponectin
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adult
Biological and medical sciences
Case-Control Studies
Cushing Syndrome - blood
Cushing Syndrome - surgery
Endocrinopathies
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Ghrelin
Humans
Hydrocortisone - blood
Hypophysectomy
Intercellular Signaling Peptides and Proteins - blood
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Peptide Hormones - blood
Postoperative Period
Regression Analysis
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary background  Ghrelin, an endogenous ligand of the GH secretagogue receptor that exerts orexigenic activity, is negatively correlated with body mass index (BMI) and insulin resistance. Conversely, low levels of adiponectin (ApN), a circulating adipocytokine with antidiabetic, antiatherogenic and anti‐inflammatory properties, have been found in several insulin‐resistant conditions. Although Cushing's syndrome causes several metabolic and hormonal changes leading to insulin resistance and central obesity, few data concerning the impact of glucocorticoid excess on ghrelin and ApN levels are so far available. design  We evaluated ghrelin and ApN levels in 14 women (age ± SE 39·5 ± 3·9 years, BMI ± SE 25·8 ± 1·4 kg/m2) with Cushing's disease (CD) at baseline and after successful transsphenoidal surgery (TSS) and in 14 age‐ and BMI‐matched healthy women. results  Despite similar levels of fasting glucose, insulin, homeostatic model assessment‐estimated insulin resistance (HOMA‐IR) and quantitative insulin sensitivity check index (QUICKI) values, patients with CD had ghrelin levels lower than controls (117·8 ± 21·5 vs. 269·6 ± 51·4 pmol/l, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2004.02169.x