Children with early-onset inflammatory bowel disease (IBD): Analysis of a pediatric IBD consortium registry

To determine the characteristics of inflammatory bowel disease (IBD) in young patients. Uniform data were collected from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium). Of 1370 children in the registry, the mean...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2005, Vol.146 (1), p.35-40
Main Authors: Heyman, Melvin B., Kirschner, Barbara S., Gold, Benjamin D., Ferry, George, Baldassano, Robert, Cohen, Stanley A., Winter, Harland S., Fain, Patricia, King, Chris, Smith, Terry, El-Serag, Hashem B.
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Child
Child, Preschool
Cohort Studies
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - genetics
Crohn Disease - diagnosis
Crohn Disease - epidemiology
Crohn Disease - genetics
Demography
Female
Humans
Infant
Male
Registries - statistics & numerical data
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine the characteristics of inflammatory bowel disease (IBD) in young patients. Uniform data were collected from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium). Of 1370 children in the registry, the mean age at IBD diagnosis was 10.3 ± 4.4 years; 54% were male, and 86% were white. Diagnosis was confirmed in 87 (6.1%) under 3 years of age, 211 (15.4%) before 6 years, 654 (47.7%) at 6 to 12 years, and 505 (36.9%) at 13 to 17 years. More than 63% of children younger than 8 years of age had isolated colonic disease, whether Crohn disease, ulcerative colitis (UC), or indeterminate colitis. Conversely, only 35% of those 8 years of age or older had isolated colonic disease ( P < .0001). Overall, 29% had one or more family members with IBD. The subgroup of children younger than 3 years of age with UC had the highest prevalence of first-degree relatives with IBD (44%). This demographically diverse pediatric IBD cohort revealed age-related variation in the distribution of IBD phenotype, with a high prevalence of isolated colonic disease in young children. Positive family history was especially common in young patients with UC.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2004.08.043