Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-01 (4), p.447-449
Main Authors: Flenniken, Michelle L, Liepold, Lars O, Crowley, Bridgid E, Willits, Deborah A, Young, Mark J, Douglas, Trevor
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Doxorubicin - chemistry
Drug Delivery Systems - methods
Electrophoresis, Polyacrylamide Gel
Heat-Shock Proteins - chemistry
Heat-Shock Proteins - genetics
Methanococcus - chemistry
Protein Engineering
Protein Subunits - chemistry
Protein Subunits - genetics
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Description
Summary:The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.
ISSN:1359-7345
1364-548X
DOI:10.1039/b413435d