Reference values from M-mode and Doppler echocardiography for normal Syrian hamsters

Echocardiography has recently been introduced to small animal research, allowing serial measurements of cardiac diseases. In addition, the hamster model has been increasingly used, as it mimics many human heart conditions. However, no reference range of echocardiographic values reflecting normal lef...

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Bibliographic Details
Published in:European journal of echocardiography 2005-01, Vol.6 (1), p.41-46
Main Authors: Salemi, Vera M C, Bilate, Angelina M B, Ramires, Félix J A, Picard, Michael H, Gregio, Daniel M, Kalil, Jorge, Neto, Edécio Cunha, Mady, Charles
Format: Article
Language:English
Subjects:
Animals
Cricetinae
Diastole - physiology
Echocardiography - standards
Echocardiography, Doppler - standards
Female
Heart Rate
Heart Ventricles - anatomy & histology
Heart Ventricles - diagnostic imaging
Mesocricetus
Models, Animal
Reference Values
Systole - physiology
Ventricular Function, Left
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Summary:Echocardiography has recently been introduced to small animal research, allowing serial measurements of cardiac diseases. In addition, the hamster model has been increasingly used, as it mimics many human heart conditions. However, no reference range of echocardiographic values reflecting normal left ventricular (LV) function exists for hamsters. The purpose of this study was to provide one. The study group consisted of 118 10-week-old, female, Syrian golden hamsters, which underwent high-resolution echocardiography. LV mass was calculated using the corrected cube formula, and LV systolic and diastolic function were assessed by fractional shortening and mitral inflow pulsed-wave Doppler, respectively. The myocardial performance index (MPI) measured the time spent in isovolumic activity and reflected both systolic and diastolic function. The mean+/-SD LV mass, fractional shortening, and MPI were 0.19+/-0.04 g, 44.7+/-6.6%, and 0.39+/-0.1, respectively. E and A waves were differentiated in 52% of all animals. Logistic regression adjusted with a cutoff of 378 bpm revealed that the risk of E/A wave fusion was 35 times greater (95% CI: 12.6; 98.4) in animals with a heart rate >378 bpm. This study documents echocardiographic characteristics in normal Syrian hamsters, which can be used as control values for future studies.
ISSN:1525-2167
DOI:10.1016/j.euje.2004.06.001