Morphofunctional Study of the Therapeutic Efficacy of Human Mesenchymal and Neural Stem Cells in Rats with Diffuse Brain Injury

• Published in: Bulletin of experimental biology and medicine 2009, Vol.147 (1), p.132-146
• Main Authors: Tsyb, A. F, Yuzhakov, V. V, Roshal', L. M, Sukhikh, G. T, Konoplyannikov, A. G, Sushkevich, G. N, Yakovleva, N. D, Ingel', I. E, Bandurko, L. N, Sevan'kaeva, L. E, Mikhina, L. N, Fomina, N. K, Marei, M. V, Semenova, Zh. B, Konoplyannikova, O. A, Kal'sina, S. Sh, Lepekhina, L. A, Semenkova, I. V, Agaeva, E. V, Shevchuk, A. S, Pavlova, L. N, Tokarev, O. Yu, Karaseva, O. V, Chernyshova, T. A
• Format: Article
• Language: English
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain Injuries - therapy; brain trauma; Cell Biology; Internal Medicine; Laboratory Medicine; Male; mesenchymal stem cells; Mesenchymal Stem Cells - cytology; neural stem cells; neurogenesis; Neurons - cytology; Pathology; Rats; Rats, Wistar; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); xenotransplantation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0432-3

We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.