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Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography–diode array detector method using liquid–liquid extraction
An HPLC system using a new, simple and rapid liquid–liquid extraction and high-performance liquid chromatography–diode array detector method (HPLC–DAD) detection was validated to determine tramadol concentration in rabbit plasma. The method described was applied to a pharmacokinetic study of intrave...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.203-208 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c362t-ddd524c1a78c1b41c12f64dcaadf0db4930e13a625fcc9bb3ae4d3e1ccd6f76e3 |
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| cites | cdi_FETCH-LOGICAL-c362t-ddd524c1a78c1b41c12f64dcaadf0db4930e13a625fcc9bb3ae4d3e1ccd6f76e3 |
| container_end_page | 208 |
| container_issue | 1 |
| container_start_page | 203 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 816 |
| creator | KÜCÜK, Aysel KADIOGLU, Yücel CELEBI, Fikret |
| description | An HPLC system using a new, simple and rapid liquid–liquid extraction and high-performance liquid chromatography–diode array detector method (HPLC–DAD) detection was validated to determine tramadol concentration in rabbit plasma. The method described was applied to a pharmacokinetic study of intravenous tramadol injections in rabbits. The extraction with ethylacetate yielded good response. The recovery of tramadol from plasma averaged 90.40%. Serial plasma samples were obtained prior to, during and after completion of the infusion for determination of tramadol concentrations. Tramadol concentrations were measured using reverse-phase high-performance liquid chromatography and pharmacokinetic application with intravenous tramadol in rabbits revealed that tramadol followed one-compartment open model. Maximum plasma concentration (
C
max) and area under the plasma concentration–time curve (AUC) for tramadol were 14.3
μg
mL
−1 and 42.2
μg
h
mL
−1, respectively. The method developed was successfully applied to a simple, rapid, specific, sensitive and accurate HPLC method for investigation of the pharmacokinetics of tramadol in rabbit plasma. |
| doi_str_mv | 10.1016/j.jchromb.2004.11.031 |
| format | article |
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C
max) and area under the plasma concentration–time curve (AUC) for tramadol were 14.3
μg
mL
−1 and 42.2
μg
h
mL
−1, respectively. The method developed was successfully applied to a simple, rapid, specific, sensitive and accurate HPLC method for investigation of the pharmacokinetics of tramadol in rabbit plasma.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2004.11.031</identifier><identifier>PMID: 15664351</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - blood ; Analgesics, Opioid - pharmacokinetics ; Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid - methods ; Drug Stability ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; HPLC ; Injections, Intravenous ; Medical sciences ; Pharmacokinetics ; Pharmacology. Drug treatments ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity ; Tramadol ; Tramadol - administration & dosage ; Tramadol - blood ; Tramadol - pharmacokinetics</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.203-208</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-ddd524c1a78c1b41c12f64dcaadf0db4930e13a625fcc9bb3ae4d3e1ccd6f76e3</citedby><cites>FETCH-LOGICAL-c362t-ddd524c1a78c1b41c12f64dcaadf0db4930e13a625fcc9bb3ae4d3e1ccd6f76e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16451376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15664351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KÜCÜK, Aysel</creatorcontrib><creatorcontrib>KADIOGLU, Yücel</creatorcontrib><creatorcontrib>CELEBI, Fikret</creatorcontrib><title>Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography–diode array detector method using liquid–liquid extraction</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>An HPLC system using a new, simple and rapid liquid–liquid extraction and high-performance liquid chromatography–diode array detector method (HPLC–DAD) detection was validated to determine tramadol concentration in rabbit plasma. The method described was applied to a pharmacokinetic study of intravenous tramadol injections in rabbits. The extraction with ethylacetate yielded good response. The recovery of tramadol from plasma averaged 90.40%. Serial plasma samples were obtained prior to, during and after completion of the infusion for determination of tramadol concentrations. Tramadol concentrations were measured using reverse-phase high-performance liquid chromatography and pharmacokinetic application with intravenous tramadol in rabbits revealed that tramadol followed one-compartment open model. Maximum plasma concentration (
C
max) and area under the plasma concentration–time curve (AUC) for tramadol were 14.3
μg
mL
−1 and 42.2
μg
h
mL
−1, respectively. The method developed was successfully applied to a simple, rapid, specific, sensitive and accurate HPLC method for investigation of the pharmacokinetics of tramadol in rabbit plasma.</description><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - blood</subject><subject>Analgesics, Opioid - pharmacokinetics</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Stability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HPLC</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tramadol</subject><subject>Tramadol - administration & dosage</subject><subject>Tramadol - blood</subject><subject>Tramadol - pharmacokinetics</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkU2O1DAUhCMEYoaBI4C8gV2CHSdO9wqhET8jjcQGJHbWi_3SeU0SZ2xnRO-4AwfiLpwE93SkXrKyF19VPVVl2UvBC8GFersv9qb3bmyLkvOqEKLgUjzKLsWmkbls1PfH6V83POelLC-yZyHsORcNb-TT7ELUSlWyFpfZn5vpHkOkHURyE3Mdiz2yuQc_gnE_aMJIJjCYLLMY0Y80nUkPI1g3MJqYh7alyOYBwgisPTBgPe36fEbfueQ1GWQD3S1k2cPZEN3Ow9wf_v76bclZZOA9HB5CTHSejRh7Z9kSaNqtyoSuFvgzZZvjHc-zJx0MAV-s71X27eOHr9ef89svn26u39_mRqoy5tbauqyMgGZjRFsJI8pOVdYA2I7bttpKjkKCKuvOmG3bSsDKShTGWNU1CuVV9ubkO3t3t6TG9EjB4DDAhG4JWjVSbdSWJ7A-gca7EDx2evY0gj9owfVxOb3X63L6uJwWQqflku7VGrC0I9qzap0qAa9XAIKBofOpUwpnTlUJalTi3p04THXcE3odDGHq35JP1Wrr6D-n_AMjycOK</recordid><startdate>20050225</startdate><enddate>20050225</enddate><creator>KÜCÜK, Aysel</creator><creator>KADIOGLU, Yücel</creator><creator>CELEBI, Fikret</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050225</creationdate><title>Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography–diode array detector method using liquid–liquid extraction</title><author>KÜCÜK, Aysel ; KADIOGLU, Yücel ; CELEBI, Fikret</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-ddd524c1a78c1b41c12f64dcaadf0db4930e13a625fcc9bb3ae4d3e1ccd6f76e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - blood</topic><topic>Analgesics, Opioid - pharmacokinetics</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Stability</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HPLC</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tramadol</topic><topic>Tramadol - administration & dosage</topic><topic>Tramadol - blood</topic><topic>Tramadol - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KÜCÜK, Aysel</creatorcontrib><creatorcontrib>KADIOGLU, Yücel</creatorcontrib><creatorcontrib>CELEBI, Fikret</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KÜCÜK, Aysel</au><au>KADIOGLU, Yücel</au><au>CELEBI, Fikret</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography–diode array detector method using liquid–liquid extraction</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2005-02-25</date><risdate>2005</risdate><volume>816</volume><issue>1</issue><spage>203</spage><epage>208</epage><pages>203-208</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>An HPLC system using a new, simple and rapid liquid–liquid extraction and high-performance liquid chromatography–diode array detector method (HPLC–DAD) detection was validated to determine tramadol concentration in rabbit plasma. The method described was applied to a pharmacokinetic study of intravenous tramadol injections in rabbits. The extraction with ethylacetate yielded good response. The recovery of tramadol from plasma averaged 90.40%. Serial plasma samples were obtained prior to, during and after completion of the infusion for determination of tramadol concentrations. Tramadol concentrations were measured using reverse-phase high-performance liquid chromatography and pharmacokinetic application with intravenous tramadol in rabbits revealed that tramadol followed one-compartment open model. Maximum plasma concentration (
C
max) and area under the plasma concentration–time curve (AUC) for tramadol were 14.3
μg
mL
−1 and 42.2
μg
h
mL
−1, respectively. The method developed was successfully applied to a simple, rapid, specific, sensitive and accurate HPLC method for investigation of the pharmacokinetics of tramadol in rabbit plasma.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15664351</pmid><doi>10.1016/j.jchromb.2004.11.031</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.203-208 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67368690 |
| source | ScienceDirect Freedom Collection |
| subjects | Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology HPLC Injections, Intravenous Medical sciences Pharmacokinetics Pharmacology. Drug treatments Rabbits Reproducibility of Results Sensitivity and Specificity Tramadol Tramadol - administration & dosage Tramadol - blood Tramadol - pharmacokinetics |
| title | Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography–diode array detector method using liquid–liquid extraction |
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