MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans

To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans. A total of 432 patients with MI and 430 controls were inclu...

Full description

Saved in:
Bibliographic Details
Published in:Clinical biochemistry 2009-07, Vol.42 (10), p.1071-1075
Main Authors: Yang, Xin-Chun, Zhang, Qi, Chen, Mu-Lei, Li, Qiang, Yang, Zhong-Su, Li, Lei, Cao, Fei-Fei, Chen, Xing-Dong, Liu, Wen-Juan, Jin, Li, Wang, Xiao-Feng
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group - genetics
Association
China
Cyclin-Dependent Kinase Inhibitor p15 - genetics
Female
Genetic Predisposition to Disease
Genetics
Genome, Human - genetics
Humans
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - enzymology
Myocardial Infarction - genetics
Odds Ratio
Polymorphism
Polymorphism, Single Nucleotide - genetics
Purine-Nucleoside Phosphorylase - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans. A total of 432 patients with MI and 430 controls were included in the study. Nine polymorphisms in the MTAP gene, two polymorphisms in the CDKN2A gene, and two polymorphisms in the CDKN2B gene were selected using a tagging single nucleotide polymorphism (tSNP) strategy. We observed that rs7027989 in the MTAP gene, and rs3217992 and rs1063192 in the CDKN2B gene were significantly associated with MI in male subjects. For rs7027989 and rs3217992, male subjects with the AA or AG genotypes had 1.26-fold and 1.24-fold increased risk of MI, respectively, compared with those with the GG genotype. For rs1063192, the G allele was associated with a reduced risk of MI with a per-allele OR of 0.71 in male subjects. The risk of rs7027989 and rs1063192 remained significant after adjusting for covariates. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2009.02.021