All D-VIP mitigates vasodilation elicited by L-VIP, micellar L-VIP and micellar PACAP1-38, but not PACAP1-38, in vivo

The purpose of this study was to determine whether all D-vasoactive intestinal peptide (VIP), an inactive optical isomer of L-VIP, modulates the vasorelaxant effects of human L-VIP and pituitary adenylate cyclase activating peptide (PACAP)1-38, two ubiquitous and pleiotropic neuropeptides that activ...

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Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2005-03, Vol.26 (3), p.509-515
Main Authors: RUBINSTEIN, Israel, ASHOK, Beena, TSUESHITA, Takaya, ÖNYÜKSEL, Hayat
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Biological and medical sciences
Bradykinin - pharmacology
Cheek - blood supply
Cheek - pathology
Cricetinae
Fundamental and applied biological sciences. Psychology
Humans
Micelles
Microcirculation
Neuropeptides - metabolism
Nitroglycerin - pharmacology
Peptide Fragments - metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide
Protein Isoforms
Protein Structure, Secondary
Receptors, Vasoactive Intestinal Peptide - metabolism
Receptors, Vasoactive Intestinal Peptide, Type II
Receptors, Vasoactive Intestinal Polypeptide, Type I
Stereoisomerism
Time Factors
Vasoactive Intestinal Peptide - pharmacology
Vasodilator Agents - pharmacology
Vertebrates: endocrinology
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Summary:The purpose of this study was to determine whether all D-vasoactive intestinal peptide (VIP), an inactive optical isomer of L-VIP, modulates the vasorelaxant effects of human L-VIP and pituitary adenylate cyclase activating peptide (PACAP)1-38, two ubiquitous and pleiotropic neuropeptides that activate VPAC1 and VPAC2, two VIP subtype receptors, in the intact peripheral microcirculation. Using intravital microscopy, we found that suffusion of all D-VIP had no significant effects on arteriolar diameter in the intact hamster cheek pouch. However, all D-VIP significantly attenuated L-VIP-induced vasodilation in a concentration-dependent fashion (P
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2004.10.016