Case-control association study of the close homologue of L1 ( CHL1) gene and schizophrenia in the Chinese population

The close homolog of L1 ( CHL1), located on human chromosome 3p26.1, is a newly identified member of the L1 family of cell adhesion molecules which play important roles in cell migration, axonal growth, and synaptic remodeling. A positive association has been reported between a missense polymorphism...

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Bibliographic Details
Published in:Schizophrenia research 2005-03, Vol.73 (2), p.269-274
Main Authors: Chen, Qing-Ying, Chen, Qi, Feng, Guo-Yin, Lindpaintner, Klaus, Chen, Yi, Sun, Xiaodong, Chen, Zhengxiong, Gao, Zhensong, Tang, Jisheng, He, Lin
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Asian Continental Ancestry Group - genetics
Association
Biological and medical sciences
Case-control
Case-Control Studies
Cell Adhesion Molecules
China
Chinese
CHL1
Chromosomes, Human, Pair 3 - genetics
DNA Primers
Female
Gene Frequency
Genotype
Humans
Japan
Male
Medical sciences
Membrane Proteins
Mutation, Missense - genetics
Neural Cell Adhesion Molecule L1 - genetics
Polymorphism, Genetic - genetics
Proteins - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - ethnology
Schizophrenia - genetics
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Summary:The close homolog of L1 ( CHL1), located on human chromosome 3p26.1, is a newly identified member of the L1 family of cell adhesion molecules which play important roles in cell migration, axonal growth, and synaptic remodeling. A positive association has been reported between a missense polymorphism in CHL1 gene and schizophrenia in the Japanese population [Sakurai, K., Migita, O., Toru, M., Arinami, T., 2002. An association between a missense polymorphism in the close homologue of L1 ( CHL1, CALL) gene and schizophrenia. Mol. Psychiatry 7, 412-415]. An association between a missense polymorphism in the close homologue of L1 ( CHL1, CALL) gene and schizophrenia. In order to test this finding, we genotyped four SNPs in the gene in the Han Chinese population using a sample of 560 cases and 576 controls. Analysis of allele frequencies in both samples also showed strong association between SNP rs2272522 (the same marker studied by K. Sakurai) and the disease ( X 2=31.591, P
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2004.06.001