Effect of Tactivin on Functional Disturbances in Avoidance Reaction in Rats

Experiments on outbred albino rats showed that tactivin (thymic polypeptide preparation) reduced functional disturbances in active avoidance reaction induced by extra electric current exposure violating the established relationships between the stimuli, reaction, and its result. The preparation prov...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009, Vol.147 (1), p.70-72
Main Authors: Kiseleva, N. M, Novoseletskaya, A. V, Zimina, I. V, Inozemtsev, A. N, Arion, V. Ya
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
avoidance reaction
Biomedical and Life Sciences
Biomedicine
Cell Biology
dysfunction
Internal Medicine
Laboratory Medicine
Male
Pathology
Peptides - pharmacology
Rats
stress
tactivin
Thymus Extracts - pharmacology
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Summary:Experiments on outbred albino rats showed that tactivin (thymic polypeptide preparation) reduced functional disturbances in active avoidance reaction induced by extra electric current exposure violating the established relationships between the stimuli, reaction, and its result. The preparation provided high level of avoidance reaction after its violation. New effects of immunocorrective agent tactivin were detected. It not only restored the disordered immunological parameters, but also exhibited a pronounced effect on the higher integrative functions of the brain and produced an antistress effect.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0446-x