Hyperprolactinaemia does not always mean ‘hyperprolactinaemia’

The presence of macroprolactinaemia was investigated in the symptom-free hyperprolactinaemia cases to reveal its incidence. The serum prolactin (PRL) fractions in 21 female patients with hyperprolactinaemia without any clinical symptoms were analyzed with PEG (polyethylene glycol precipitation) proc...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2005-02, Vol.118 (2), p.206-208
Main Authors: Gezer, Altay, Atasü, Turgay, Hekim, Can, Stenman, Ulf H., Hekim, Nezih
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chemical Precipitation
Endocrinopathies
False Positive Reactions
Female
Gynecology. Andrology. Obstetrics
Humans
Hyperprolactinaemia
Hyperprolactinemia - blood
Hypothalamus. Hypophysis. Epiphysis (diseases)
Macroprolactin
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Neoplasms - blood
Polyethylene Glycols
Prolactin
Prolactin - blood
Prolactinoma - blood
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Summary:The presence of macroprolactinaemia was investigated in the symptom-free hyperprolactinaemia cases to reveal its incidence. The serum prolactin (PRL) fractions in 21 female patients with hyperprolactinaemia without any clinical symptoms were analyzed with PEG (polyethylene glycol precipitation) procedure. In 14 of these 21 cases, hyperprolactinaemia was detected with a high fraction of macroprolactin. In cases with asymptomatic hyperprolactinaemia, it is more appropriate to employ the PEG precipitation test to detect the disorder. High levels of serum prolactin, do not essentially indicate the presence of a prolactinoma but may only indicate macroprolactinaemia.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2004.06.020