Gene expression profiling in chronic inflammatory demyelinating polyneuropathy

Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-02, Vol.159 (1), p.203-214
Main Authors: Renaud, Susanne, Hays, Arthur P., Brannagan, Thomas H., Sander, Howard W., Edgar, Mark, Weimer, Louis H., Olarte, Marcelo R., Dalakas, Marinos C., Xiang, Zhaoying, Danon, Moris J., Latov, Norman
Format: Article
Language:English
Subjects:
Adult
Aged
AIF-1
Chronic Disease
CIDP
Demyelinating Diseases - genetics
Demyelinating Diseases - pathology
Female
Gene Expression Profiling - methods
Humans
Male
Microarray
Middle Aged
Nerve biopsy
Oligonucleotide Array Sequence Analysis - methods
Polyneuropathies - genetics
Polyneuropathies - pathology
Reverse Transcriptase Polymerase Chain Reaction
SCD
Signal Transduction - genetics
Sural Nerve - pathology
TAC1
Up-Regulation
Vasculitic neuropathy
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Summary:Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2004.10.021