Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were ob...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-02, Vol.159 (1), p.215-224
Main Authors: Zhang, Rongzhen, Gascon, Ron, Miller, Robert G., Gelinas, Deborah F., Mass, Jason, Hadlock, Ken, Jin, Xia, Reis, Jeremy, Narvaez, Amy, McGrath, Michael S.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alzheimer's disease (AD)
Amyotrophic lateral sclerosis (ALS)
Amyotrophic Lateral Sclerosis - drug therapy
Amyotrophic Lateral Sclerosis - immunology
Amyotrophic Lateral Sclerosis - pathology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
Cross-Sectional Studies
Disease Progression
Female
Humans
Immune activation
Immune System - immunology
Immune System - metabolism
Immune System - pathology
Immunoglobulin G - blood
Immunoglobulin M - blood
Immunosuppression
Lymphocyte Activation
Macrophage Activation
Male
Middle Aged
Monocyte/macrophage
Motor neuron disease
Severity of Illness Index
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Description
Summary:Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2004.10.009