Synchronization of Midbrain Dopaminergic Neurons Is Enhanced by Rewarding Events

The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We stu...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2009-06, Vol.62 (5), p.695-704
Main Authors: Joshua, Mati, Adler, Avital, Prut, Yifat, Vaadia, Eilon, Wickens, Jeffery R., Bergman, Hagai
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Basal Ganglia - cytology
Behavior, Animal
Brain
Conditioning, Classical - physiology
Cues
Dopamine - metabolism
Electrodes
Female
Macaca fascicularis
Male
Neural Pathways - physiology
Neurons
Neurons - classification
Neurons - physiology
Noise
Parkinson's disease
Reward
Statistics as Topic
Studies
SYSNEURO
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Summary:The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2009.04.026