Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans

To assess the relation between aortic valve sclerosis (AVS) and subsequent occurrence of coronary heart disease (CHD) events, we analyzed echocardiographic data obtained from 2,279 middle-aged African-Americans enrolled in the Jackson Mississippi Atherosclerosis Risk in Communities study cohort who...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2005-02, Vol.95 (3), p.401-404
Main Authors: Taylor, Herman A., Clark, Bobby L., Garrison, Robert J., Andrew, Michael E., Han, Hui, Fox, Ervin R., Arnett, Donna K., Samdarshi, Tandaw, Jones, Daniel W.
Format: Article
Language:English
Subjects:
African Americans
African Americans - statistics & numerical data
Aged
Aortic Valve - pathology
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Chi-Square Distribution
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - ethnology
Coronary Disease - diagnostic imaging
Coronary Disease - epidemiology
Coronary Disease - ethnology
Coronary heart disease
Coronary vessels
Echocardiography
Female
Health risk assessment
Heart
Humans
Incidence
Male
Medical sciences
Middle Aged
Mississippi - epidemiology
Prevalence
Proportional Hazards Models
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the relation between aortic valve sclerosis (AVS) and subsequent occurrence of coronary heart disease (CHD) events, we analyzed echocardiographic data obtained from 2,279 middle-aged African-Americans enrolled in the Jackson Mississippi Atherosclerosis Risk in Communities study cohort who were free of known CHD at the time of the examination. Cox regression analyses demonstrated a hazard ratio of 3.8 for incident first myocardial infarction or fatal CHD after adjusted for multiple risk factors, including markers of inflammation. An amplification of CHD risk in the AVS subgroup with high levels of serum inflammatory markers (the highest quartile of fibrinogen and von Willebrand Factor levels) demonstrated greater than fivefold higher risk of CHD associated with AVS than risk in the lowest quartile.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.09.043