Evaluation of Oligo(ethylene glycol) Dimethacrylates Effects on the Properties of New Biodegradable Bone Cement Compositions

• Published in: Macromolecular bioscience 2005-01, Vol.5 (1), p.64-69
• Main Authors: Łukaszczyk, Jan, Śmiga, Monika, Jaszcz, Katarzyna, Adler, Hans-Jürgen P., Jähne, Evelyn, Kaczmarek, Marcin
• Format: Article
• Language: English
• Subjects: Applied sciences; Biocompatible Materials - chemistry; biodegradable polyesters; bone cement; Bone Cements - chemistry; Chemical properties; Dose-Response Relationship, Drug; Ethylene Glycol - chemistry; Exact sciences and technology; mechanical properties; Methacrylates - chemistry; Models, Chemical; orthopedic biomaterials; Polymer industry, paints, wood; Polymers - chemistry; Polypropylenes; Properties and testing; Succinic Anhydrides - chemistry; Technology of polymers; Temperature; Time Factors; Water
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.200400135

New injectable, in situ curable liquid formulations consisting of biodegradable aliphatic polyester, i.e., poly(3‐allyloxy‐1,2‐propylene)succinate (PSAGE), methyl methacrylate (MMA), and hydrophilic oligo(ethylene glycol) dimethacrylates (OEGDMA) were investigated. The effect of MMA/OEGDMA ratio, OEGDMA molecular weight, i.e., the length of oligooxyethylene fragments, on the maximum curing temperature, setting time, compressive strength and modulus of the cured materials as well as their hydrophilicity were examined. The latter was characterized by determination of equilibrium water content and static water contact angle. The maximum temperature during crosslinking was found to decrease with increasing OEGDMA molecular weight and decreasing MMA/OEGDMA ratio. The setting time was affected strongly by the concentration of double bonds and was rapidly shortened with its increase. The compressive strength and compressive modulus values decreased with increasing OEGDMA molecular weight and decreasing MMA/OEGDMA ratio. Poly(3‐allyloxy‐1,2‐propylene succinate).