Liver transplantation utilizing pediatric cadaver donor livers

:  This is a review of a unit's experience with the use of pediatric (up to 15 yr of age), cadaver donor livers for orthotopic liver transplantation (OLTx). The records of 86 patients who underwent 90 OLTx with pediatric donor allografts from January 1986 to September 2002 were reviewed. A tota...

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Published in:Pediatric transplantation 2005-02, Vol.9 (1), p.47-51
Main Authors: Tanaka, Hideaki, Verran, Deborah, Shun, Albert, Dorney, Stuart, Stormon, Michael, Fisher, Jodi, McCaughan, Geoff
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cadaver
Cause of Death
Child
Female
General aspects
Graft Rejection
Graft Survival
Humans
liver
Liver Transplantation - mortality
Male
Medical sciences
pediatric
transplantation
Transplantation, Homologous
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cited_by cdi_FETCH-LOGICAL-c4356-a4d03e79867b8d1876ad3d5c02ab45a7945428bba0b6ec322db5762d38f9efc63
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container_end_page 51
container_issue 1
container_start_page 47
container_title Pediatric transplantation
container_volume 9
creator Tanaka, Hideaki
Verran, Deborah
Shun, Albert
Dorney, Stuart
Stormon, Michael
Fisher, Jodi
McCaughan, Geoff
description :  This is a review of a unit's experience with the use of pediatric (up to 15 yr of age), cadaver donor livers for orthotopic liver transplantation (OLTx). The records of 86 patients who underwent 90 OLTx with pediatric donor allografts from January 1986 to September 2002 were reviewed. A total of 69 of 90 (77%) allografts from pediatric donors were used for pediatric (P) recipients, and 21 of 90 (23%) for adult (A) recipients. Donor demographics were: mean donor age 8.5 (0–15) yr; donor sex 53 males/37 females; cause of death head injury 55/90 (61%), cerebral ischaemia 14 of 90 (15%), cerebrovascular 13 of 90 (15%), other eight of 90 (9%). Whole OLTx were performed in 44 of 69 (64%) P group and 20 of 21 (95%) A group. Reduced‐size OLTx (13 left lateral lobe, 10 left lobe, one right lobe, one split left lateral lobe) were performed in 25 of 69 (36%) P group vs. in one of 21 (5%) A group, (right lobe split) (p 
doi_str_mv 10.1111/j.1399-3046.2005.00246.x
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The records of 86 patients who underwent 90 OLTx with pediatric donor allografts from January 1986 to September 2002 were reviewed. A total of 69 of 90 (77%) allografts from pediatric donors were used for pediatric (P) recipients, and 21 of 90 (23%) for adult (A) recipients. Donor demographics were: mean donor age 8.5 (0–15) yr; donor sex 53 males/37 females; cause of death head injury 55/90 (61%), cerebral ischaemia 14 of 90 (15%), cerebrovascular 13 of 90 (15%), other eight of 90 (9%). Whole OLTx were performed in 44 of 69 (64%) P group and 20 of 21 (95%) A group. Reduced‐size OLTx (13 left lateral lobe, 10 left lobe, one right lobe, one split left lateral lobe) were performed in 25 of 69 (36%) P group vs. in one of 21 (5%) A group, (right lobe split) (p &lt; 0.005). The median follow up was 8.8 yr. The graft loss in the P recipients was 19 of 69 (27.5%) vs. eight of 21 (38.1%) in A recipients. Graft loss for reduced size P OLTx was nine of 25 (36%) vs. 10/44 (22.7%) for whole allograft P OLTx (p = NS). Underlying cause of P graft loss were: chronic rejection six (32%); patient mortality six (32%); vascular four (21%); other three (15%). Underlying cause of A graft loss were: patient mortality four (50%), acute rejection two (25%) and vascular two (25%). OLTx‐utilizing pediatric cadaver donor allografts provides acceptable outcomes, including use of reduced‐size grafts in pediatric recipients. Vascular complications and chronic rejection tend to be more common in pediatric recipients, whilst patient mortality and graft loss from acute rejection are more common in adult recipients.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/j.1399-3046.2005.00246.x</identifier><identifier>PMID: 15667611</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cadaver ; Cause of Death ; Child ; Female ; General aspects ; Graft Rejection ; Graft Survival ; Humans ; liver ; Liver Transplantation - mortality ; Male ; Medical sciences ; pediatric ; transplantation ; Transplantation, Homologous</subject><ispartof>Pediatric transplantation, 2005-02, Vol.9 (1), p.47-51</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-a4d03e79867b8d1876ad3d5c02ab45a7945428bba0b6ec322db5762d38f9efc63</citedby><cites>FETCH-LOGICAL-c4356-a4d03e79867b8d1876ad3d5c02ab45a7945428bba0b6ec322db5762d38f9efc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16668335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15667611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Hideaki</creatorcontrib><creatorcontrib>Verran, Deborah</creatorcontrib><creatorcontrib>Shun, Albert</creatorcontrib><creatorcontrib>Dorney, Stuart</creatorcontrib><creatorcontrib>Stormon, Michael</creatorcontrib><creatorcontrib>Fisher, Jodi</creatorcontrib><creatorcontrib>McCaughan, Geoff</creatorcontrib><title>Liver transplantation utilizing pediatric cadaver donor livers</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>:  This is a review of a unit's experience with the use of pediatric (up to 15 yr of age), cadaver donor livers for orthotopic liver transplantation (OLTx). The records of 86 patients who underwent 90 OLTx with pediatric donor allografts from January 1986 to September 2002 were reviewed. A total of 69 of 90 (77%) allografts from pediatric donors were used for pediatric (P) recipients, and 21 of 90 (23%) for adult (A) recipients. Donor demographics were: mean donor age 8.5 (0–15) yr; donor sex 53 males/37 females; cause of death head injury 55/90 (61%), cerebral ischaemia 14 of 90 (15%), cerebrovascular 13 of 90 (15%), other eight of 90 (9%). Whole OLTx were performed in 44 of 69 (64%) P group and 20 of 21 (95%) A group. Reduced‐size OLTx (13 left lateral lobe, 10 left lobe, one right lobe, one split left lateral lobe) were performed in 25 of 69 (36%) P group vs. in one of 21 (5%) A group, (right lobe split) (p &lt; 0.005). The median follow up was 8.8 yr. The graft loss in the P recipients was 19 of 69 (27.5%) vs. eight of 21 (38.1%) in A recipients. Graft loss for reduced size P OLTx was nine of 25 (36%) vs. 10/44 (22.7%) for whole allograft P OLTx (p = NS). Underlying cause of P graft loss were: chronic rejection six (32%); patient mortality six (32%); vascular four (21%); other three (15%). Underlying cause of A graft loss were: patient mortality four (50%), acute rejection two (25%) and vascular two (25%). OLTx‐utilizing pediatric cadaver donor allografts provides acceptable outcomes, including use of reduced‐size grafts in pediatric recipients. Vascular complications and chronic rejection tend to be more common in pediatric recipients, whilst patient mortality and graft loss from acute rejection are more common in adult recipients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cadaver</subject><subject>Cause of Death</subject><subject>Child</subject><subject>Female</subject><subject>General aspects</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>liver</subject><subject>Liver Transplantation - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>pediatric</subject><subject>transplantation</subject><subject>Transplantation, Homologous</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkMtKxDAYRoMo3l9ButFdx9yTLhQc8YaDiiiCm5AmqWTstGPS0dGnN3UG3ZpNPsj5kj8HgAzBAUrrcDxApChyAikfYAjZAEKc4nwFbP4erP5kkRNE8QbYinEMIeJU0nWwgRjngiO0CY5H_t2FrAu6idNaN53ufNtks87X_ss3L9nUWa-74E1mtNU9a9umDVnd9-IOWKt0Hd3uct8Gj-dnD6eX-ej24ur0ZJQbShjPNbWQOFFILkppkRRcW2KZgViXlGlRUEaxLEsNS-4MwdiWTHBsiawKVxlOtsHB4t5paN9mLnZq4qNxdZrYtbOouCASQiISKBegCW2MwVVqGvxEh0-FoOrdqbHqFalekerdqR93ap6qe8s3ZuXE2b_iUlYC9peAjkbXVXJmfPzjOOeSEJa4owX34Wv3-e8B1N3Zw31KqZ8v-j52bv7b1-G1_6dg6unmQuFnOLx-uhyqEfkGYMmZoQ</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Tanaka, Hideaki</creator><creator>Verran, Deborah</creator><creator>Shun, Albert</creator><creator>Dorney, Stuart</creator><creator>Stormon, Michael</creator><creator>Fisher, Jodi</creator><creator>McCaughan, Geoff</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Liver transplantation utilizing pediatric cadaver donor livers</title><author>Tanaka, Hideaki ; Verran, Deborah ; Shun, Albert ; Dorney, Stuart ; Stormon, Michael ; Fisher, Jodi ; McCaughan, Geoff</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-a4d03e79867b8d1876ad3d5c02ab45a7945428bba0b6ec322db5762d38f9efc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cadaver</topic><topic>Cause of Death</topic><topic>Child</topic><topic>Female</topic><topic>General aspects</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>liver</topic><topic>Liver Transplantation - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>pediatric</topic><topic>transplantation</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Hideaki</creatorcontrib><creatorcontrib>Verran, Deborah</creatorcontrib><creatorcontrib>Shun, Albert</creatorcontrib><creatorcontrib>Dorney, Stuart</creatorcontrib><creatorcontrib>Stormon, Michael</creatorcontrib><creatorcontrib>Fisher, Jodi</creatorcontrib><creatorcontrib>McCaughan, Geoff</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Hideaki</au><au>Verran, Deborah</au><au>Shun, Albert</au><au>Dorney, Stuart</au><au>Stormon, Michael</au><au>Fisher, Jodi</au><au>McCaughan, Geoff</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver transplantation utilizing pediatric cadaver donor livers</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2005-02</date><risdate>2005</risdate><volume>9</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>:  This is a review of a unit's experience with the use of pediatric (up to 15 yr of age), cadaver donor livers for orthotopic liver transplantation (OLTx). The records of 86 patients who underwent 90 OLTx with pediatric donor allografts from January 1986 to September 2002 were reviewed. A total of 69 of 90 (77%) allografts from pediatric donors were used for pediatric (P) recipients, and 21 of 90 (23%) for adult (A) recipients. Donor demographics were: mean donor age 8.5 (0–15) yr; donor sex 53 males/37 females; cause of death head injury 55/90 (61%), cerebral ischaemia 14 of 90 (15%), cerebrovascular 13 of 90 (15%), other eight of 90 (9%). Whole OLTx were performed in 44 of 69 (64%) P group and 20 of 21 (95%) A group. Reduced‐size OLTx (13 left lateral lobe, 10 left lobe, one right lobe, one split left lateral lobe) were performed in 25 of 69 (36%) P group vs. in one of 21 (5%) A group, (right lobe split) (p &lt; 0.005). The median follow up was 8.8 yr. The graft loss in the P recipients was 19 of 69 (27.5%) vs. eight of 21 (38.1%) in A recipients. Graft loss for reduced size P OLTx was nine of 25 (36%) vs. 10/44 (22.7%) for whole allograft P OLTx (p = NS). Underlying cause of P graft loss were: chronic rejection six (32%); patient mortality six (32%); vascular four (21%); other three (15%). Underlying cause of A graft loss were: patient mortality four (50%), acute rejection two (25%) and vascular two (25%). OLTx‐utilizing pediatric cadaver donor allografts provides acceptable outcomes, including use of reduced‐size grafts in pediatric recipients. Vascular complications and chronic rejection tend to be more common in pediatric recipients, whilst patient mortality and graft loss from acute rejection are more common in adult recipients.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15667611</pmid><doi>10.1111/j.1399-3046.2005.00246.x</doi><tpages>5</tpages></addata></record>
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1399-3046
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subjects Adolescent
Adult
Biological and medical sciences
Cadaver
Cause of Death
Child
Female
General aspects
Graft Rejection
Graft Survival
Humans
liver
Liver Transplantation - mortality
Male
Medical sciences
pediatric
transplantation
Transplantation, Homologous
title Liver transplantation utilizing pediatric cadaver donor livers
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