In vivo 19F MR imaging and spectroscopy for the BNCT optimization

The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine ( 19F-BPA) using 19 F MR Imaging ( 19 F MRI) and Spectroscopy ( 19 F MRS). The correlation between the results obtained by both techniques, 19 F MRI on rat brain and 19 F MR...

Full description

Saved in:
Bibliographic Details
Published in:Applied radiation and isotopes 2009-07, Vol.67 (7), p.S365-S368
Main Authors: Porcari, P., Capuani, S., D’Amore, E., Lecce, M., La Bella, A., Fasano, F., Migneco, L.M., Campanella, R., Maraviglia, B., Pastore, F.S.
Format: Article
Language:English
Subjects:
19F MRI
19F MRS
19F-BPA
Animal model
Animals
BNCT
Boron Compounds - pharmacokinetics
Boron Compounds - therapeutic use
Boron Neutron Capture Therapy - methods
BPA
Brain Neoplasms - metabolism
Brain Neoplasms - radiotherapy
C6 glioma
Cell Line, Tumor
Fluorine - analysis
Fluorine - pharmacokinetics
Glioma - metabolism
Glioma - radiotherapy
In Vitro Techniques
L-DOPA
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
MRI
Phenylalanine - analogs & derivatives
Phenylalanine - pharmacokinetics
Phenylalanine - therapeutic use
Radiation-Sensitizing Agents - pharmacokinetics
Radiation-Sensitizing Agents - therapeutic use
Rat brain
Rats
Rats, Wistar
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine ( 19F-BPA) using 19 F MR Imaging ( 19 F MRI) and Spectroscopy ( 19 F MRS). The correlation between the results obtained by both techniques, 19 F MRI on rat brain and 19 F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5 h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.03.065