99mTc Nanocoll: A radiopharmaceutical for sentinel node localisation in breast cancer—In vitro and in vivo results

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher...

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-09, Vol.67 (9), p.1550-1558
Main Authors: Gommans, G.M.M., Gommans, E., van der Zant, F.M., Teule, G.J.J., van der Schors, T.G., de Waard, J.W.D.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Albumins
Breast Neoplasms - diagnostic imaging
Colloid albumin
Female
Humans
Labelling efficiency
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
Middle Aged
Nitrogen - chemistry
Radiochemical purity
Radionuclide Imaging
Radiopharmaceuticals
Radiopharmacy
Sentinel Lymph Node Biopsy
Sentinel node
Technetium Tc 99m Aggregated Albumin
Young Adult
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Summary:This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2h eluate in vacuum or nitrogen. Labelling 26MBq/μg 99mTc colloid albumin with a 2h eluate under nitrogen is recommended because of the ease of labelling.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.02.091