New approach to incorporation of boron in tumor-seeking molecules

Cyclic oxonium derivatives of polyhedral boron hydrides have great potential for modification of various types of tumor seeking biomolecules and are very promising starting materials for synthesis of BNCT (boron neutron capture therapy) agents.

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-07, Vol.67 (7), p.S91-S93
Main Authors: Sivaev, I.B., Semioshkin, A.A., Bregadze, V.I.
Format: Article
Language:English
Subjects:
Biomolecules
Boron Compounds - chemical synthesis
Boron Compounds - chemistry
Boron Compounds - therapeutic use
Boron neutron capture therapy
Boron Neutron Capture Therapy - methods
Cyclic oxonium derivatives
Drug Design
Functionalization
Humans
Molecular Structure
Neoplasms - radiotherapy
Polyhedral boron hydrides
Radiation-Sensitizing Agents - chemical synthesis
Radiation-Sensitizing Agents - chemistry
Radiation-Sensitizing Agents - therapeutic use
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Description
Summary:Cyclic oxonium derivatives of polyhedral boron hydrides have great potential for modification of various types of tumor seeking biomolecules and are very promising starting materials for synthesis of BNCT (boron neutron capture therapy) agents.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.03.022