Improvement of dose distribution in phantom by using epithermal neutron source based on the Be(p,n) reaction using a 30 MeV proton cyclotron accelerator

• Published in: Applied radiation and isotopes 2009-07, Vol.67 (7), p.S258-S261
• Main Authors: Tanaka, H., Sakurai, Y., Suzuki, M., Takata, T., Masunaga, S., Kinashi, Y., Kashino, G., Liu, Y., Mitsumoto, T., Yajima, S., Tsutsui, H., Takada, M., Maruhashi, A., Ono, K.
• Format: Article
• Language: English
• Subjects: Be(p,n) reaction; Beryllium; Biophysical Phenomena; Boron Neutron Capture Therapy - instrumentation; Boron Neutron Capture Therapy - methods; Boron Neutron Capture Therapy - statistics & numerical data; Cyclotron-based neutron source; Cyclotrons - statistics & numerical data; Fast Neutrons - therapeutic use; Humans; Monte Carlo Method; Phantoms, Imaging - statistics & numerical data; Proton cyclotron; Protons
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2009.03.096

In order to generate epithermal neutrons for boron neutron capture therapy (BNCT), we proposed the method of filtering and moderating fast neutrons, which are emitted from the reaction between a beryllium target and 30 MeV protons accelerated by a cyclotron, using an optimum moderator system composed of iron, lead, aluminum, calcium fluoride, and enriched 6LiF ceramic filter. At present, the epithermal-neutron source is under construction since June 2008 at Kyoto University Research Reactor Institute. This system consists of a cyclotron to supply a proton beam of about 1 mA at 30 MeV, a beam transport system, a beam scanner system for heat reduction on the beryllium target, a target cooling system, a beam shaping assembly, and an irradiation bed for patients. In this article, an overview of the cyclotron-based neutron source (CBNS) and the properties of the treatment neutron beam optimized by using the MCNPX Monte Carlo code are presented. The distribution of the RBE (relative biological effectiveness) dose in a phantom shows that, assuming a 10B concentration of 13 ppm for normal tissue, this beam could be employed to treat a patient with an irradiation time less than 30 min and a dose less than 12.5 Gy-eq to normal tissue. The CBNS might be an alternative to the reactor-based neutron sources for BNCT treatments.